Autoantibody biomarkers in childhood-acquired demyelinating syndromes: Results from a national surveillance cohort

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Autoantibody biomarkers in childhood-acquired demyelinating syndromes : Results from a national surveillance cohort. / Hacohen, Yael; Absoud, Michael; Woodhall, Mark; Cummins, Carole; De Goede, Christian G.; Hemingway, Cheryl; Jardine, Philip E.; Kneen, Rachel; Pike, Michael G.; Whitehouse, William P.; Wassmer, Evangeline; Waters, Patrick; Vincent, Angela; Lim, Ming.

In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 85, No. 4, 2014, p. 456-461.

Research output: Contribution to journalArticle

Harvard

Hacohen, Y, Absoud, M, Woodhall, M, Cummins, C, De Goede, CG, Hemingway, C, Jardine, PE, Kneen, R, Pike, MG, Whitehouse, WP, Wassmer, E, Waters, P, Vincent, A & Lim, M 2014, 'Autoantibody biomarkers in childhood-acquired demyelinating syndromes: Results from a national surveillance cohort', Journal of Neurology Neurosurgery and Psychiatry, vol. 85, no. 4, pp. 456-461. https://doi.org/10.1136/jnnp-2013-306411

APA

Hacohen, Y., Absoud, M., Woodhall, M., Cummins, C., De Goede, C. G., Hemingway, C., Jardine, P. E., Kneen, R., Pike, M. G., Whitehouse, W. P., Wassmer, E., Waters, P., Vincent, A., & Lim, M. (2014). Autoantibody biomarkers in childhood-acquired demyelinating syndromes: Results from a national surveillance cohort. Journal of Neurology Neurosurgery and Psychiatry, 85(4), 456-461. https://doi.org/10.1136/jnnp-2013-306411

Vancouver

Author

Hacohen, Yael ; Absoud, Michael ; Woodhall, Mark ; Cummins, Carole ; De Goede, Christian G. ; Hemingway, Cheryl ; Jardine, Philip E. ; Kneen, Rachel ; Pike, Michael G. ; Whitehouse, William P. ; Wassmer, Evangeline ; Waters, Patrick ; Vincent, Angela ; Lim, Ming. / Autoantibody biomarkers in childhood-acquired demyelinating syndromes : Results from a national surveillance cohort. In: Journal of Neurology Neurosurgery and Psychiatry. 2014 ; Vol. 85, No. 4. pp. 456-461.

Bibtex

@article{73f8be109cab4f2a897a76b39eb28dfd,
title = "Autoantibody biomarkers in childhood-acquired demyelinating syndromes: Results from a national surveillance cohort",
abstract = "Background: Autoantibodies to glial, myelin and neuronal antigens have been reported in a range of central demyelination syndromes and autoimmune encephalopathies in children, but there has not been a systematic evaluation across the range of central nervous system (CNS) autoantibodies in childhood-acquired demyelinating syndromes (ADS). Methods: Children under the age of 16 years with first-episode ADS were identified from a national prospective surveillance study; serum from 65 patients had been sent for a variety of diagnostic tests. Antibodies to astrocyte, myelin and neuronal antigens were tested or retested in all samples. Results: Fifteen patients (23%) were positive for at least one antibody (Ab): AQ4-Ab was detected in three; two presenting with neuromyelitis optica (NMO) and one with isolated optic neuritis (ON). Myelin oligodendrocyte glycoprotein (MOG)-Ab was detected in seven; two with acute disseminated encephalomyelitis (ADEM), two with ON, one with transverse myelitis (TM) and two with clinically isolated syndrome (CIS). N-Methyl-D-Aspartate receptor (NMDAR)-Ab was found in two; one presenting with ADEM and one with ON. Voltage-gated potassium channel (VGKC)-complex antibodies were positive in three; one presenting with ADEM, one with ON and one with CIS. GlyR-Ab was detected in one patient with TM. All patients were negative for the VGKC-complex-associated proteins LGI1, CASPR2 and contactin-2. Conclusions: A range of CNS-directed autoantibodies were found in association with childhood ADS. Although these antibodies are clinically relevant when associated with the specific neurological syndromes that have been described, further studies are required to evaluate their roles and clinical relevance in demyelinating diseases.",
author = "Yael Hacohen and Michael Absoud and Mark Woodhall and Carole Cummins and {De Goede}, {Christian G.} and Cheryl Hemingway and Jardine, {Philip E.} and Rachel Kneen and Pike, {Michael G.} and Whitehouse, {William P.} and Evangeline Wassmer and Patrick Waters and Angela Vincent and Ming Lim",
year = "2014",
doi = "10.1136/jnnp-2013-306411",
language = "English",
volume = "85",
pages = "456--461",
journal = "Journal of Neurology Neurosurgery and Psychiatry",
issn = "0022-3050",
publisher = "BMJ Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Autoantibody biomarkers in childhood-acquired demyelinating syndromes

T2 - Results from a national surveillance cohort

AU - Hacohen, Yael

AU - Absoud, Michael

AU - Woodhall, Mark

AU - Cummins, Carole

AU - De Goede, Christian G.

AU - Hemingway, Cheryl

AU - Jardine, Philip E.

AU - Kneen, Rachel

AU - Pike, Michael G.

AU - Whitehouse, William P.

AU - Wassmer, Evangeline

AU - Waters, Patrick

AU - Vincent, Angela

AU - Lim, Ming

PY - 2014

Y1 - 2014

N2 - Background: Autoantibodies to glial, myelin and neuronal antigens have been reported in a range of central demyelination syndromes and autoimmune encephalopathies in children, but there has not been a systematic evaluation across the range of central nervous system (CNS) autoantibodies in childhood-acquired demyelinating syndromes (ADS). Methods: Children under the age of 16 years with first-episode ADS were identified from a national prospective surveillance study; serum from 65 patients had been sent for a variety of diagnostic tests. Antibodies to astrocyte, myelin and neuronal antigens were tested or retested in all samples. Results: Fifteen patients (23%) were positive for at least one antibody (Ab): AQ4-Ab was detected in three; two presenting with neuromyelitis optica (NMO) and one with isolated optic neuritis (ON). Myelin oligodendrocyte glycoprotein (MOG)-Ab was detected in seven; two with acute disseminated encephalomyelitis (ADEM), two with ON, one with transverse myelitis (TM) and two with clinically isolated syndrome (CIS). N-Methyl-D-Aspartate receptor (NMDAR)-Ab was found in two; one presenting with ADEM and one with ON. Voltage-gated potassium channel (VGKC)-complex antibodies were positive in three; one presenting with ADEM, one with ON and one with CIS. GlyR-Ab was detected in one patient with TM. All patients were negative for the VGKC-complex-associated proteins LGI1, CASPR2 and contactin-2. Conclusions: A range of CNS-directed autoantibodies were found in association with childhood ADS. Although these antibodies are clinically relevant when associated with the specific neurological syndromes that have been described, further studies are required to evaluate their roles and clinical relevance in demyelinating diseases.

AB - Background: Autoantibodies to glial, myelin and neuronal antigens have been reported in a range of central demyelination syndromes and autoimmune encephalopathies in children, but there has not been a systematic evaluation across the range of central nervous system (CNS) autoantibodies in childhood-acquired demyelinating syndromes (ADS). Methods: Children under the age of 16 years with first-episode ADS were identified from a national prospective surveillance study; serum from 65 patients had been sent for a variety of diagnostic tests. Antibodies to astrocyte, myelin and neuronal antigens were tested or retested in all samples. Results: Fifteen patients (23%) were positive for at least one antibody (Ab): AQ4-Ab was detected in three; two presenting with neuromyelitis optica (NMO) and one with isolated optic neuritis (ON). Myelin oligodendrocyte glycoprotein (MOG)-Ab was detected in seven; two with acute disseminated encephalomyelitis (ADEM), two with ON, one with transverse myelitis (TM) and two with clinically isolated syndrome (CIS). N-Methyl-D-Aspartate receptor (NMDAR)-Ab was found in two; one presenting with ADEM and one with ON. Voltage-gated potassium channel (VGKC)-complex antibodies were positive in three; one presenting with ADEM, one with ON and one with CIS. GlyR-Ab was detected in one patient with TM. All patients were negative for the VGKC-complex-associated proteins LGI1, CASPR2 and contactin-2. Conclusions: A range of CNS-directed autoantibodies were found in association with childhood ADS. Although these antibodies are clinically relevant when associated with the specific neurological syndromes that have been described, further studies are required to evaluate their roles and clinical relevance in demyelinating diseases.

UR - http://www.scopus.com/inward/record.url?scp=84895810416&partnerID=8YFLogxK

U2 - 10.1136/jnnp-2013-306411

DO - 10.1136/jnnp-2013-306411

M3 - Article

C2 - 24133290

AN - SCOPUS:84895810416

VL - 85

SP - 456

EP - 461

JO - Journal of Neurology Neurosurgery and Psychiatry

JF - Journal of Neurology Neurosurgery and Psychiatry

SN - 0022-3050

IS - 4

ER -