Atypical dorsolateral prefrontal activity in females with conduct disorder during effortful emotion regulation

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Atypical dorsolateral prefrontal activity in females with conduct disorder during effortful emotion regulation. / Raschle, Nora Maria; Fehlbaum, Lynn Valérie; Menks, Willeke Martine; Martinelli, Anne; Prätzlich, Martin; Bernhard, Anka; Ackermann, Katharina; Freitag, Christine M.; De Brito, Stephane; Fairchild, Graeme; Stadler, Christina.

In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, Vol. 4, No. 11, 11.2019, p. 984-994.

Research output: Contribution to journalArticle

Harvard

Raschle, NM, Fehlbaum, LV, Menks, WM, Martinelli, A, Prätzlich, M, Bernhard, A, Ackermann, K, Freitag, CM, De Brito, S, Fairchild, G & Stadler, C 2019, 'Atypical dorsolateral prefrontal activity in females with conduct disorder during effortful emotion regulation', Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, vol. 4, no. 11, pp. 984-994. https://doi.org/10.1016/j.bpsc.2019.05.003

APA

Raschle, N. M., Fehlbaum, L. V., Menks, W. M., Martinelli, A., Prätzlich, M., Bernhard, A., Ackermann, K., Freitag, C. M., De Brito, S., Fairchild, G., & Stadler, C. (2019). Atypical dorsolateral prefrontal activity in females with conduct disorder during effortful emotion regulation. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 4(11), 984-994. https://doi.org/10.1016/j.bpsc.2019.05.003

Vancouver

Author

Raschle, Nora Maria ; Fehlbaum, Lynn Valérie ; Menks, Willeke Martine ; Martinelli, Anne ; Prätzlich, Martin ; Bernhard, Anka ; Ackermann, Katharina ; Freitag, Christine M. ; De Brito, Stephane ; Fairchild, Graeme ; Stadler, Christina. / Atypical dorsolateral prefrontal activity in females with conduct disorder during effortful emotion regulation. In: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging. 2019 ; Vol. 4, No. 11. pp. 984-994.

Bibtex

@article{644d7429fd744a35a3b39a740f73d252,
title = "Atypical dorsolateral prefrontal activity in females with conduct disorder during effortful emotion regulation",
abstract = "Background: Conduct disorder (CD), which is characterized by severe aggressive and antisocial behavior, is linked to emotion processing and regulation deficits. However, the neural correlates of emotion regulation are yet to be investigated in adolescents with CD. Furthermore, it remains unclear whether CD is associated with deficits in emotional reactivity, emotion regulation, or both. Methods: We used functional magnetic resonance imaging to study effortful emotion regulation by cognitive reappraisal in 59 female adolescents 15 to 18 years of age (30 with a CD diagnosis and 29 typically developing (TD) control adolescents). Results: Behaviorally, in-scanner self-report ratings confirmed successful emotion regulation within each group individually but significant group differences in emotional reactivity and reappraisal success when comparing the groups (CD < TD). Functional magnetic resonance imaging results revealed significantly lower activation in left dorsolateral prefrontal cortex and angular gyrus in CD compared with TD adolescents during emotion regulation, but no group differences for emotional reactivity. Furthermore, connectivity between left dorsolateral prefrontal cortex and the bilateral putamen, right prefrontal cortex, and amygdala was reduced in CD compared with TD adolescents during reappraisal. Callous-unemotional traits were unrelated to neural activation, but these traits correlated negatively with behavioral reports of emotional reactivity. Conclusions: Our results demonstrate reduced prefrontal brain activity and functional connectivity during effortful emotion regulation in female adolescents with CD. This sheds light on the neural basis of the behavioral deficits that have been reported previously. Future studies should investigate whether cognitive interventions are effective in enhancing emotion-regulation abilities and/or normalizing prefrontal and temporoparietal activity in female adolescents with CD.",
keywords = "Conduct disorder, Dorsolateral prefrontal cortex, Emotion processing, Emotion regulation, Female adolescents, fMRI",
author = "Raschle, {Nora Maria} and Fehlbaum, {Lynn Val{\'e}rie} and Menks, {Willeke Martine} and Anne Martinelli and Martin Pr{\"a}tzlich and Anka Bernhard and Katharina Ackermann and Freitag, {Christine M.} and {De Brito}, Stephane and Graeme Fairchild and Christina Stadler",
year = "2019",
month = nov,
doi = "10.1016/j.bpsc.2019.05.003",
language = "English",
volume = "4",
pages = "984--994",
journal = "Biological Psychiatry: Cognitive Neuroscience and Neuroimaging",
issn = "2451-9022",
publisher = "Elsevier",
number = "11",

}

RIS

TY - JOUR

T1 - Atypical dorsolateral prefrontal activity in females with conduct disorder during effortful emotion regulation

AU - Raschle, Nora Maria

AU - Fehlbaum, Lynn Valérie

AU - Menks, Willeke Martine

AU - Martinelli, Anne

AU - Prätzlich, Martin

AU - Bernhard, Anka

AU - Ackermann, Katharina

AU - Freitag, Christine M.

AU - De Brito, Stephane

AU - Fairchild, Graeme

AU - Stadler, Christina

PY - 2019/11

Y1 - 2019/11

N2 - Background: Conduct disorder (CD), which is characterized by severe aggressive and antisocial behavior, is linked to emotion processing and regulation deficits. However, the neural correlates of emotion regulation are yet to be investigated in adolescents with CD. Furthermore, it remains unclear whether CD is associated with deficits in emotional reactivity, emotion regulation, or both. Methods: We used functional magnetic resonance imaging to study effortful emotion regulation by cognitive reappraisal in 59 female adolescents 15 to 18 years of age (30 with a CD diagnosis and 29 typically developing (TD) control adolescents). Results: Behaviorally, in-scanner self-report ratings confirmed successful emotion regulation within each group individually but significant group differences in emotional reactivity and reappraisal success when comparing the groups (CD < TD). Functional magnetic resonance imaging results revealed significantly lower activation in left dorsolateral prefrontal cortex and angular gyrus in CD compared with TD adolescents during emotion regulation, but no group differences for emotional reactivity. Furthermore, connectivity between left dorsolateral prefrontal cortex and the bilateral putamen, right prefrontal cortex, and amygdala was reduced in CD compared with TD adolescents during reappraisal. Callous-unemotional traits were unrelated to neural activation, but these traits correlated negatively with behavioral reports of emotional reactivity. Conclusions: Our results demonstrate reduced prefrontal brain activity and functional connectivity during effortful emotion regulation in female adolescents with CD. This sheds light on the neural basis of the behavioral deficits that have been reported previously. Future studies should investigate whether cognitive interventions are effective in enhancing emotion-regulation abilities and/or normalizing prefrontal and temporoparietal activity in female adolescents with CD.

AB - Background: Conduct disorder (CD), which is characterized by severe aggressive and antisocial behavior, is linked to emotion processing and regulation deficits. However, the neural correlates of emotion regulation are yet to be investigated in adolescents with CD. Furthermore, it remains unclear whether CD is associated with deficits in emotional reactivity, emotion regulation, or both. Methods: We used functional magnetic resonance imaging to study effortful emotion regulation by cognitive reappraisal in 59 female adolescents 15 to 18 years of age (30 with a CD diagnosis and 29 typically developing (TD) control adolescents). Results: Behaviorally, in-scanner self-report ratings confirmed successful emotion regulation within each group individually but significant group differences in emotional reactivity and reappraisal success when comparing the groups (CD < TD). Functional magnetic resonance imaging results revealed significantly lower activation in left dorsolateral prefrontal cortex and angular gyrus in CD compared with TD adolescents during emotion regulation, but no group differences for emotional reactivity. Furthermore, connectivity between left dorsolateral prefrontal cortex and the bilateral putamen, right prefrontal cortex, and amygdala was reduced in CD compared with TD adolescents during reappraisal. Callous-unemotional traits were unrelated to neural activation, but these traits correlated negatively with behavioral reports of emotional reactivity. Conclusions: Our results demonstrate reduced prefrontal brain activity and functional connectivity during effortful emotion regulation in female adolescents with CD. This sheds light on the neural basis of the behavioral deficits that have been reported previously. Future studies should investigate whether cognitive interventions are effective in enhancing emotion-regulation abilities and/or normalizing prefrontal and temporoparietal activity in female adolescents with CD.

KW - Conduct disorder

KW - Dorsolateral prefrontal cortex

KW - Emotion processing

KW - Emotion regulation

KW - Female adolescents

KW - fMRI

UR - http://www.scopus.com/inward/record.url?scp=85068794932&partnerID=8YFLogxK

U2 - 10.1016/j.bpsc.2019.05.003

DO - 10.1016/j.bpsc.2019.05.003

M3 - Article

C2 - 31311717

VL - 4

SP - 984

EP - 994

JO - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

JF - Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

SN - 2451-9022

IS - 11

ER -