Atrial natriuretic peptide regulates regional vascular volume and venous tone in humans

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

OBJECTIVE: To date, the contribution of basal atrial natriuretic peptide (ANP) levels to resting vascular function in humans is unknown. In the present study we sought to investigate the role of ANP in regulating regional vascular volume and venous tone in healthy subjects. METHODS AND RESULTS: We used radionuclide plethysmography to examine the effects of ANP and the ANP-receptor antagonist A71915 on forearm vascular volume. Creating pressure/volume relations, we determined changes in vascular volume, compliance, and tone. Performing dose-ranging studies, we additionally assessed the potency and specificity of A71915 in the forearm resistance vasculature. Equilibrium blood pool scintigraphy was then used to assess the effects of systemic administration of A71915 on regional intestinal vascular volume. Infusion of ANP increased forearm vascular volume in a dose-dependent manner (maximum 20%; P

Details

Original languageEnglish
Pages (from-to)1833-1838
Number of pages6
JournalArteriosclerosis Thrombosis and Vascular Biology
Volume23
Publication statusPublished - 28 Aug 2003