Asymmetry of language activation relates to regional callosal morphology following early cerebral injury

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Asymmetry of language activation relates to regional callosal morphology following early cerebral injury. / Wood, Amanda; Saling, M M; Jackson, G D; Reutens, D C.

In: Epilepsy & Behavior, Vol. 12, No. 3, 04.2008, p. 427-33.

Research output: Contribution to journalArticlepeer-review

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Wood, Amanda ; Saling, M M ; Jackson, G D ; Reutens, D C. / Asymmetry of language activation relates to regional callosal morphology following early cerebral injury. In: Epilepsy & Behavior. 2008 ; Vol. 12, No. 3. pp. 427-33.

Bibtex

@article{c909b701025f41998113585d57b9b138,
title = "Asymmetry of language activation relates to regional callosal morphology following early cerebral injury",
abstract = "The anatomical factors underlying reorganization of language representation are yet to be elucidated, although correlations between asymmetric structures and language lateralization have been identified. Previous research has implicated the corpus callosum in the development of language lateralization. This study examined the relationship between callosal morphology and language asymmetry, using letter fluency functional magnetic resonance imaging, in 13 patients with focal epilepsy and 8 healthy controls. Regional callosal thickness was determined without relying on a priori delineation of callosal segments. We predicted that language asymmetry measured by fMRI activation laterality scores would be correlated with regional callosal thickness in both groups. However, only the degree of language activation asymmetry was significantly correlated with callosal thickness in the isthmus and the midbody of patients, and there was a significant interaction between the groups with respect to callosal thickness and language activation asymmetry. These data suggest that callosal pathways may be important for language reorganization in the context of early cerebral injury.",
keywords = "Adult, Brain Injuries, Brain Mapping, Cerebral Cortex, Corpus Callosum, Female, Functional Laterality, Humans, Image Processing, Computer-Assisted, Language Tests, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Verbal Behavior",
author = "Amanda Wood and Saling, {M M} and Jackson, {G D} and Reutens, {D C}",
year = "2008",
month = apr,
doi = "10.1016/j.yebeh.2007.12.020",
language = "English",
volume = "12",
pages = "427--33",
journal = "Epilepsy & Behavior",
issn = "1525-5050",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Asymmetry of language activation relates to regional callosal morphology following early cerebral injury

AU - Wood, Amanda

AU - Saling, M M

AU - Jackson, G D

AU - Reutens, D C

PY - 2008/4

Y1 - 2008/4

N2 - The anatomical factors underlying reorganization of language representation are yet to be elucidated, although correlations between asymmetric structures and language lateralization have been identified. Previous research has implicated the corpus callosum in the development of language lateralization. This study examined the relationship between callosal morphology and language asymmetry, using letter fluency functional magnetic resonance imaging, in 13 patients with focal epilepsy and 8 healthy controls. Regional callosal thickness was determined without relying on a priori delineation of callosal segments. We predicted that language asymmetry measured by fMRI activation laterality scores would be correlated with regional callosal thickness in both groups. However, only the degree of language activation asymmetry was significantly correlated with callosal thickness in the isthmus and the midbody of patients, and there was a significant interaction between the groups with respect to callosal thickness and language activation asymmetry. These data suggest that callosal pathways may be important for language reorganization in the context of early cerebral injury.

AB - The anatomical factors underlying reorganization of language representation are yet to be elucidated, although correlations between asymmetric structures and language lateralization have been identified. Previous research has implicated the corpus callosum in the development of language lateralization. This study examined the relationship between callosal morphology and language asymmetry, using letter fluency functional magnetic resonance imaging, in 13 patients with focal epilepsy and 8 healthy controls. Regional callosal thickness was determined without relying on a priori delineation of callosal segments. We predicted that language asymmetry measured by fMRI activation laterality scores would be correlated with regional callosal thickness in both groups. However, only the degree of language activation asymmetry was significantly correlated with callosal thickness in the isthmus and the midbody of patients, and there was a significant interaction between the groups with respect to callosal thickness and language activation asymmetry. These data suggest that callosal pathways may be important for language reorganization in the context of early cerebral injury.

KW - Adult

KW - Brain Injuries

KW - Brain Mapping

KW - Cerebral Cortex

KW - Corpus Callosum

KW - Female

KW - Functional Laterality

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Language Tests

KW - Magnetic Resonance Imaging

KW - Male

KW - Neuropsychological Tests

KW - Oxygen

KW - Verbal Behavior

U2 - 10.1016/j.yebeh.2007.12.020

DO - 10.1016/j.yebeh.2007.12.020

M3 - Article

C2 - 18249586

VL - 12

SP - 427

EP - 433

JO - Epilepsy & Behavior

JF - Epilepsy & Behavior

SN - 1525-5050

IS - 3

ER -