Asymmetric Synthesis of cis-3,4-Dihydrocoumarins via [4 + 2] Cycloadditions Catalyzed by Amidine Derivatives

Research output: Contribution to journalArticlepeer-review


  • Jing Hai Jin
  • Xiang Yu Li
  • Xiaoyan Luo
  • John Fossey
  • Wei Ping Deng

Colleges, School and Institutes

External organisations

  • East China University of Science and Technology


A highly efficient chiral amidine derivative-catalyzed tandem Michael addition/lactonization of carboxylic acids and o-quinone methides (o-QMs) has been developed that enables the asymmetric synthesis of cis-3,4-dihydrocoumarins bearing contiguous tertiary stereogenic centers in high yields with excellent stereoselectivities.


Original languageEnglish
Pages (from-to)5424-5432
Number of pages9
JournalJournal of Organic Chemistry
Issue number10
Early online date25 Apr 2017
Publication statusPublished - 19 May 2017

ASJC Scopus subject areas