Association of two apolipoprotein A-I gene MspI polymorphisms with HDL-cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early onset Type 2 diabetes

YQ Ma; Graham Thomas; MCY Ng; JAJH Critchley; CS Cockram; JCN Chan; B Tomlinson

doi:10.1046/j.1365-2265.2003.01865.x

Association of two apolipoprotein A-I gene MspI polymorphisms with HDL-cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early onset Type 2 diabetes

YQ Ma, Graham Thomas, MCY Ng, JAJH Critchley, CS Cockram, JCN Chan, B Tomlinson

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Abstract

OBJECTIVE: Previous studies have reported associations between two apolipoprotein A-I (apoA-I) gene MspI polymorphisms (G-75A and C83T) and high density lipoprotein (HDL)-cholesterol and/or apoA-I levels, but have not investigated the relationship with obesity. METHODS: We determined the distribution of these polymorphisms in 482 early-onset (<or = 40 years) Type 2 Chinese diabetics and 167 Chinese selected healthy controls. RESULTS: The -75A and 83T allele frequencies were similar in the diabetic and healthy subjects. In the healthy control subjects, HDL-cholesterol levels were significantly higher in the AA homozygotes than in the GG/GA carriers (1.74 +/- 0.58 vs. 1.45 +/- 0.58 mmol/l, P

Original language	English
Pages (from-to)	442-449
Number of pages	8
Journal	Clinical Endocrinology
Volume	59
DOIs	https://doi.org/10.1046/j.1365-2265.2003.01865.x
Publication status	Published - 1 Oct 2003

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Ma, YQ., Thomas, G., Ng, MCY., Critchley, JAJH., Cockram, CS., Chan, JCN., & Tomlinson, B. (2003). Association of two apolipoprotein A-I gene MspI polymorphisms with HDL-cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early onset Type 2 diabetes. Clinical Endocrinology, 59, 442-449. https://doi.org/10.1046/j.1365-2265.2003.01865.x

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title = "Association of two apolipoprotein A-I gene MspI polymorphisms with HDL-cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early onset Type 2 diabetes",

abstract = "OBJECTIVE: Previous studies have reported associations between two apolipoprotein A-I (apoA-I) gene MspI polymorphisms (G-75A and C83T) and high density lipoprotein (HDL)-cholesterol and/or apoA-I levels, but have not investigated the relationship with obesity. METHODS: We determined the distribution of these polymorphisms in 482 early-onset (<or = 40 years) Type 2 Chinese diabetics and 167 Chinese selected healthy controls. RESULTS: The -75A and 83T allele frequencies were similar in the diabetic and healthy subjects. In the healthy control subjects, HDL-cholesterol levels were significantly higher in the AA homozygotes than in the GG/GA carriers (1.74 +/- 0.58 vs. 1.45 +/- 0.58 mmol/l, P",

author = "YQ Ma and Graham Thomas and MCY Ng and JAJH Critchley and CS Cockram and JCN Chan and B Tomlinson",

year = "2003",

month = oct,

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doi = "10.1046/j.1365-2265.2003.01865.x",

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Ma, YQ, Thomas, G, Ng, MCY, Critchley, JAJH, Cockram, CS, Chan, JCN & Tomlinson, B 2003, 'Association of two apolipoprotein A-I gene MspI polymorphisms with HDL-cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early onset Type 2 diabetes', Clinical Endocrinology, vol. 59, pp. 442-449. https://doi.org/10.1046/j.1365-2265.2003.01865.x

TY - JOUR

T1 - Association of two apolipoprotein A-I gene MspI polymorphisms with HDL-cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early onset Type 2 diabetes

AU - Ma, YQ

AU - Thomas, Graham

AU - Ng, MCY

AU - Critchley, JAJH

AU - Cockram, CS

AU - Chan, JCN

AU - Tomlinson, B

PY - 2003/10/1

Y1 - 2003/10/1

N2 - OBJECTIVE: Previous studies have reported associations between two apolipoprotein A-I (apoA-I) gene MspI polymorphisms (G-75A and C83T) and high density lipoprotein (HDL)-cholesterol and/or apoA-I levels, but have not investigated the relationship with obesity. METHODS: We determined the distribution of these polymorphisms in 482 early-onset (<or = 40 years) Type 2 Chinese diabetics and 167 Chinese selected healthy controls. RESULTS: The -75A and 83T allele frequencies were similar in the diabetic and healthy subjects. In the healthy control subjects, HDL-cholesterol levels were significantly higher in the AA homozygotes than in the GG/GA carriers (1.74 +/- 0.58 vs. 1.45 +/- 0.58 mmol/l, P

AB - OBJECTIVE: Previous studies have reported associations between two apolipoprotein A-I (apoA-I) gene MspI polymorphisms (G-75A and C83T) and high density lipoprotein (HDL)-cholesterol and/or apoA-I levels, but have not investigated the relationship with obesity. METHODS: We determined the distribution of these polymorphisms in 482 early-onset (<or = 40 years) Type 2 Chinese diabetics and 167 Chinese selected healthy controls. RESULTS: The -75A and 83T allele frequencies were similar in the diabetic and healthy subjects. In the healthy control subjects, HDL-cholesterol levels were significantly higher in the AA homozygotes than in the GG/GA carriers (1.74 +/- 0.58 vs. 1.45 +/- 0.58 mmol/l, P

U2 - 10.1046/j.1365-2265.2003.01865.x

DO - 10.1046/j.1365-2265.2003.01865.x

M3 - Article

C2 - 14510906

SN - 1365-2265

VL - 59

SP - 442

EP - 449

JO - Clinical Endocrinology

JF - Clinical Endocrinology

ER -

Association of two apolipoprotein A-I gene MspI polymorphisms with HDL-cholesterol levels and indices of obesity in selected healthy Chinese subjects and in patients with early onset Type 2 diabetes

Abstract

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