Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS

Research output: Contribution to journalArticle

Authors

Colleges, School and Institutes

Abstract

Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54).

Details

Original languageEnglish
Pages (from-to)934-937
Number of pages4
JournalNeurology
Volume65
Issue number6
Publication statusPublished - 10 Aug 2005