Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS

Emily Goodall; MJ Greenway; I van Marion; Camille Carroll; O Hardiman; Karen Morrison

doi:10.1212/01.wnl.0000176032.94434.d4

Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS

Emily Goodall, MJ Greenway, I van Marion, Camille Carroll, O Hardiman, Karen Morrison

Birmingham Medical School

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Abstract

Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54).

Original language	English
Pages (from-to)	934-937
Number of pages	4
Journal	Neurology
Volume	65
Issue number	6
DOIs	https://doi.org/10.1212/01.wnl.0000176032.94434.d4
Publication status	Published - 10 Aug 2005

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title = "Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS",

abstract = "Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54).",

author = "Emily Goodall and MJ Greenway and {van Marion}, I and Camille Carroll and O Hardiman and Karen Morrison",

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AU - Carroll, Camille

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AU - Morrison, Karen

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N2 - Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54).

AB - Iron misregulation promotes oxidative stress and abnormally high iron levels have been found in the spinal cords of patients with ALS. The authors investigated whether HFE gene polymorphisms, linked to hemochromatosis, are associated with ALS using two independent populations of patients with sporadic ALS and controls (totaling 379 patients and 400 controls). They found that the H63D polymorphism is overrepresented in individuals with sporadic ALS (odds ratio 1.85, CI: 1.35 to 2.54).

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Association of the H63D polymorphism in the hemochromatosis gene with sporadic ALS

Abstract

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