Association of the FTO (rs9939609) gene with the neural correlates of working-memory based modulation of attention to food

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@article{f60e8a7762264a91846e7db99bb81a76,
title = "Association of the FTO (rs9939609) gene with the neural correlates of working-memory based modulation of attention to food",
abstract = "Food-related stimuli in the environment attract attention because of their association with rewarding consequences. However, evidence suggests that cognitive processing of food stimuli can also influence attention via top-down control. We investigated neural responses when holding a food or non-food item in working-memory (WM) and the influence of obesity-risk gene FTO in 15 subjects. Participants were presented with a cue (food or non-food) to hold in WM. Subsequently, they had to respond to a target and ignore a distracter, both paired with a food or non-food item. Behavioural performance was more strongly affected by food cues than non-food cues held in memory (ηp2=0.215). Participants with the FTO risk allele showed a strong interaction between memory and selective attention (p<0.001, ηp2=0.617). Neuroimaging data showed an increased activation of fronto-parietal attention network when a non-food cue (vs. food) was held in WM, whereas a food-cue enhanced right hippocampal and caudate activation but only when with the target was paired with the cue (p<0.05 FWE-corrected). The latter was associated with the T-allele. Additionally, a group of 17 subjects performed the same behavioural test. Here, subjects were also faster in identifying the target (p<0.005, ηp2=0.358) when holding a food-cue in WM, however the FTO risk allele had medium effect (ηp2=0.076). The data suggest that when holding food items in WM, attention is strengthened; this is consistent with the idea that food items have a high motivational salience. This effect is modulated by the obesity-risk gene FTO, suggesting that top-down control of attention via WM might be a target for intervention in obesity.",
author = "Maartje Spetter and Femke Rutters and Jason Thomas and Dirk Dolmans and Renate Reniers and Pia Rotshtein and Suzanne Higgs",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.appet.2017.11.072",
language = "English",
volume = "123",
pages = "466",
journal = "Appetite",
issn = "0195-6663",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Association of the FTO (rs9939609) gene with the neural correlates of working-memory based modulation of attention to food

AU - Spetter, Maartje

AU - Rutters, Femke

AU - Thomas, Jason

AU - Dolmans, Dirk

AU - Reniers, Renate

AU - Rotshtein, Pia

AU - Higgs, Suzanne

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Food-related stimuli in the environment attract attention because of their association with rewarding consequences. However, evidence suggests that cognitive processing of food stimuli can also influence attention via top-down control. We investigated neural responses when holding a food or non-food item in working-memory (WM) and the influence of obesity-risk gene FTO in 15 subjects. Participants were presented with a cue (food or non-food) to hold in WM. Subsequently, they had to respond to a target and ignore a distracter, both paired with a food or non-food item. Behavioural performance was more strongly affected by food cues than non-food cues held in memory (ηp2=0.215). Participants with the FTO risk allele showed a strong interaction between memory and selective attention (p<0.001, ηp2=0.617). Neuroimaging data showed an increased activation of fronto-parietal attention network when a non-food cue (vs. food) was held in WM, whereas a food-cue enhanced right hippocampal and caudate activation but only when with the target was paired with the cue (p<0.05 FWE-corrected). The latter was associated with the T-allele. Additionally, a group of 17 subjects performed the same behavioural test. Here, subjects were also faster in identifying the target (p<0.005, ηp2=0.358) when holding a food-cue in WM, however the FTO risk allele had medium effect (ηp2=0.076). The data suggest that when holding food items in WM, attention is strengthened; this is consistent with the idea that food items have a high motivational salience. This effect is modulated by the obesity-risk gene FTO, suggesting that top-down control of attention via WM might be a target for intervention in obesity.

AB - Food-related stimuli in the environment attract attention because of their association with rewarding consequences. However, evidence suggests that cognitive processing of food stimuli can also influence attention via top-down control. We investigated neural responses when holding a food or non-food item in working-memory (WM) and the influence of obesity-risk gene FTO in 15 subjects. Participants were presented with a cue (food or non-food) to hold in WM. Subsequently, they had to respond to a target and ignore a distracter, both paired with a food or non-food item. Behavioural performance was more strongly affected by food cues than non-food cues held in memory (ηp2=0.215). Participants with the FTO risk allele showed a strong interaction between memory and selective attention (p<0.001, ηp2=0.617). Neuroimaging data showed an increased activation of fronto-parietal attention network when a non-food cue (vs. food) was held in WM, whereas a food-cue enhanced right hippocampal and caudate activation but only when with the target was paired with the cue (p<0.05 FWE-corrected). The latter was associated with the T-allele. Additionally, a group of 17 subjects performed the same behavioural test. Here, subjects were also faster in identifying the target (p<0.005, ηp2=0.358) when holding a food-cue in WM, however the FTO risk allele had medium effect (ηp2=0.076). The data suggest that when holding food items in WM, attention is strengthened; this is consistent with the idea that food items have a high motivational salience. This effect is modulated by the obesity-risk gene FTO, suggesting that top-down control of attention via WM might be a target for intervention in obesity.

U2 - 10.1016/j.appet.2017.11.072

DO - 10.1016/j.appet.2017.11.072

M3 - Abstract

VL - 123

SP - 466

JO - Appetite

JF - Appetite

SN - 0195-6663

ER -