Association of adiposity with pulmonary function in older Chinese: Guangzhou Biobank Cohort Study

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Association of adiposity with pulmonary function in older Chinese: Guangzhou Biobank Cohort Study. / Pan, Jing; Xu, Lin; Lam, Tai Hing; Jiang, Chao Qiang; Zhang, Wei Sen; Jin, Ya Li; Zhu, Feng; Zhu, Tong; Thomas, G. Neil; Cheng, Kar Keung; Adab, Peymane.

In: Respiratory Medicine, Vol. 132, 01.11.2017, p. 102-108.

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Pan, Jing ; Xu, Lin ; Lam, Tai Hing ; Jiang, Chao Qiang ; Zhang, Wei Sen ; Jin, Ya Li ; Zhu, Feng ; Zhu, Tong ; Thomas, G. Neil ; Cheng, Kar Keung ; Adab, Peymane. / Association of adiposity with pulmonary function in older Chinese: Guangzhou Biobank Cohort Study. In: Respiratory Medicine. 2017 ; Vol. 132. pp. 102-108.

Bibtex

@article{f55e47884bed4ed9833656672802cc21,
title = "Association of adiposity with pulmonary function in older Chinese:: Guangzhou Biobank Cohort Study",
abstract = "Objective We examined the association between different adiposity indices and pulmonary function in Chinese adults in the Guangzhou Biobank Cohort Study (GBCS). Methods Participants with body mass index (BMI) < 18.5 (underweight) were excluded. Adiposity indices including BMI, waist circumference (WC), waist hip ratio, waist height ratio and body fat percentage were measured. Lung function was assessed by spirometry using a turbine flowmeter. We analyzed percent predicted for forced expiratory volume in 1 s (FEV1%), forced vital capacity (FVC %) and restrictive respiratory defect (FEV1/FVC ratio > low limits of normal and FVC % <0.80). Results Of 16186 participants (mean age 61.4 ± 7.2 years; 74.0% women), 116 (0.7%) had only general obesity (BMI ≥28 kg/m2), 4079 (25.2%) had only central obesity (WC: ≥90 cm in men, ≥80 cm in women) and 1591 (9.8%) had both central obesity and general obesity. Comparing to those with neither central nor general obesity, those with only central adiposity and with both central and general obesity had lower pulmonary function (adjusted β range from -2.85 to -6.02 for FEV1% and FVC%, adjusted OR range from 1.14 to 1.70, all P < 0.05). But those with only general obesity had better but non-significant pulmonary function. (Crude β range from 1.46 to 2.92 for FEV1% and FVC%, crude OR range from 0.68 to 0.93, all P > 0.05). Both FEV1% and FVC% decreased per standard deviation increase in obesity indices (adjusted β from -0.46 to -3.17, all P < 0.002). A positive association of central or general obesity with restrictive respiratory defect was observed (adjusted odds ratio (AOR) from 1.50 to 2.04, all P < 0.002). Further adjustment for WC reversed the inverse association between BMI and pulmonary function (adjusted β from 1.93 to 6.22, all P < 0.001) and restrictive respiratory defect (adjusted AOR from 0.72 to 0.80, all P < 0.001). Conclusion Central adiposity and its indices, but not general adiposity and BMI, were independently associated with lower pulmonary function and higher risk of restrictive respiratory defect in older Chinese.",
keywords = "BMI, Central adiposity, General adiposity, Pulmonary function, Restrictive respiratory defect, WC",
author = "Jing Pan and Lin Xu and Lam, {Tai Hing} and Jiang, {Chao Qiang} and Zhang, {Wei Sen} and Jin, {Ya Li} and Feng Zhu and Tong Zhu and Thomas, {G. Neil} and Cheng, {Kar Keung} and Peymane Adab",
year = "2017",
month = nov,
day = "1",
doi = "10.1016/j.rmed.2017.10.003",
language = "English",
volume = "132",
pages = "102--108",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Association of adiposity with pulmonary function in older Chinese:

T2 - Guangzhou Biobank Cohort Study

AU - Pan, Jing

AU - Xu, Lin

AU - Lam, Tai Hing

AU - Jiang, Chao Qiang

AU - Zhang, Wei Sen

AU - Jin, Ya Li

AU - Zhu, Feng

AU - Zhu, Tong

AU - Thomas, G. Neil

AU - Cheng, Kar Keung

AU - Adab, Peymane

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Objective We examined the association between different adiposity indices and pulmonary function in Chinese adults in the Guangzhou Biobank Cohort Study (GBCS). Methods Participants with body mass index (BMI) < 18.5 (underweight) were excluded. Adiposity indices including BMI, waist circumference (WC), waist hip ratio, waist height ratio and body fat percentage were measured. Lung function was assessed by spirometry using a turbine flowmeter. We analyzed percent predicted for forced expiratory volume in 1 s (FEV1%), forced vital capacity (FVC %) and restrictive respiratory defect (FEV1/FVC ratio > low limits of normal and FVC % <0.80). Results Of 16186 participants (mean age 61.4 ± 7.2 years; 74.0% women), 116 (0.7%) had only general obesity (BMI ≥28 kg/m2), 4079 (25.2%) had only central obesity (WC: ≥90 cm in men, ≥80 cm in women) and 1591 (9.8%) had both central obesity and general obesity. Comparing to those with neither central nor general obesity, those with only central adiposity and with both central and general obesity had lower pulmonary function (adjusted β range from -2.85 to -6.02 for FEV1% and FVC%, adjusted OR range from 1.14 to 1.70, all P < 0.05). But those with only general obesity had better but non-significant pulmonary function. (Crude β range from 1.46 to 2.92 for FEV1% and FVC%, crude OR range from 0.68 to 0.93, all P > 0.05). Both FEV1% and FVC% decreased per standard deviation increase in obesity indices (adjusted β from -0.46 to -3.17, all P < 0.002). A positive association of central or general obesity with restrictive respiratory defect was observed (adjusted odds ratio (AOR) from 1.50 to 2.04, all P < 0.002). Further adjustment for WC reversed the inverse association between BMI and pulmonary function (adjusted β from 1.93 to 6.22, all P < 0.001) and restrictive respiratory defect (adjusted AOR from 0.72 to 0.80, all P < 0.001). Conclusion Central adiposity and its indices, but not general adiposity and BMI, were independently associated with lower pulmonary function and higher risk of restrictive respiratory defect in older Chinese.

AB - Objective We examined the association between different adiposity indices and pulmonary function in Chinese adults in the Guangzhou Biobank Cohort Study (GBCS). Methods Participants with body mass index (BMI) < 18.5 (underweight) were excluded. Adiposity indices including BMI, waist circumference (WC), waist hip ratio, waist height ratio and body fat percentage were measured. Lung function was assessed by spirometry using a turbine flowmeter. We analyzed percent predicted for forced expiratory volume in 1 s (FEV1%), forced vital capacity (FVC %) and restrictive respiratory defect (FEV1/FVC ratio > low limits of normal and FVC % <0.80). Results Of 16186 participants (mean age 61.4 ± 7.2 years; 74.0% women), 116 (0.7%) had only general obesity (BMI ≥28 kg/m2), 4079 (25.2%) had only central obesity (WC: ≥90 cm in men, ≥80 cm in women) and 1591 (9.8%) had both central obesity and general obesity. Comparing to those with neither central nor general obesity, those with only central adiposity and with both central and general obesity had lower pulmonary function (adjusted β range from -2.85 to -6.02 for FEV1% and FVC%, adjusted OR range from 1.14 to 1.70, all P < 0.05). But those with only general obesity had better but non-significant pulmonary function. (Crude β range from 1.46 to 2.92 for FEV1% and FVC%, crude OR range from 0.68 to 0.93, all P > 0.05). Both FEV1% and FVC% decreased per standard deviation increase in obesity indices (adjusted β from -0.46 to -3.17, all P < 0.002). A positive association of central or general obesity with restrictive respiratory defect was observed (adjusted odds ratio (AOR) from 1.50 to 2.04, all P < 0.002). Further adjustment for WC reversed the inverse association between BMI and pulmonary function (adjusted β from 1.93 to 6.22, all P < 0.001) and restrictive respiratory defect (adjusted AOR from 0.72 to 0.80, all P < 0.001). Conclusion Central adiposity and its indices, but not general adiposity and BMI, were independently associated with lower pulmonary function and higher risk of restrictive respiratory defect in older Chinese.

KW - BMI

KW - Central adiposity

KW - General adiposity

KW - Pulmonary function

KW - Restrictive respiratory defect

KW - WC

U2 - 10.1016/j.rmed.2017.10.003

DO - 10.1016/j.rmed.2017.10.003

M3 - Article

AN - SCOPUS:85031100469

VL - 132

SP - 102

EP - 108

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

ER -