TY - JOUR
T1 - Association between serum free T4 concentration and atrial fibrillation
AU - Gammage, Michael
AU - Parle, James
AU - Holder, Roger
AU - Roberts, Lesley
AU - Hobbs, Frederick
AU - Wilson, Sue
AU - Sheppard, Michael
AU - Franklyn, Jayne
PY - 2007/5/14
Y1 - 2007/5/14
N2 - BACKGROUND: Previous studies have suggested that minor changes in thyroid function are associated with risk of atrial fibrillation (AF). Our objective was to determine the relationship between thyroid function and presence of atrial fibrillation (AF) in older subjects. METHODS: A population-based study of 5860 subjects 65 years and older, which excluded those being treated for thyroid dysfunction and those with previous hyperthyroidism. Main outcome measures included tests of thyroid function (serum free thyroxine [T(4)] and thyrotropin [TSH]) and the presence of AF on resting electrocardiogram. RESULTS: Fourteen subjects (0.2%) had previously undiagnosed overt hyperthyroidism and 126 (2.2%), subclinical hyperthyroidism; 5519 (94.4%) were euthyroid; and 167 (2.9%) had subclinical hypothyroidism and 23 (0.4%), overt hypothyroidism. The prevalence of AF in the whole cohort was 6.6% in men and 3.1% in women (odds ratio, 2.23; P
AB - BACKGROUND: Previous studies have suggested that minor changes in thyroid function are associated with risk of atrial fibrillation (AF). Our objective was to determine the relationship between thyroid function and presence of atrial fibrillation (AF) in older subjects. METHODS: A population-based study of 5860 subjects 65 years and older, which excluded those being treated for thyroid dysfunction and those with previous hyperthyroidism. Main outcome measures included tests of thyroid function (serum free thyroxine [T(4)] and thyrotropin [TSH]) and the presence of AF on resting electrocardiogram. RESULTS: Fourteen subjects (0.2%) had previously undiagnosed overt hyperthyroidism and 126 (2.2%), subclinical hyperthyroidism; 5519 (94.4%) were euthyroid; and 167 (2.9%) had subclinical hypothyroidism and 23 (0.4%), overt hypothyroidism. The prevalence of AF in the whole cohort was 6.6% in men and 3.1% in women (odds ratio, 2.23; P
UR - http://www.scopus.com/inward/record.url?scp=34248507213&partnerID=8YFLogxK
U2 - 10.1001/archinte.167.9.928
DO - 10.1001/archinte.167.9.928
M3 - Article
C2 - 17502534
VL - 167
SP - 928
EP - 934
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 9
ER -