Assessment of surface roughness and blood rheology on local coronary haemodynamics: A multi-scale computational fluid dynamics study
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
External organisations
- Sheffield Hallam University
Abstract
The surface roughness of the coronary artery is associated with the onset of atherosclerosis. The study applies, for the first time, the micro-scale variation of the artery surface to a 3D coronary model, investigating the impact on haemodynamic parameters which are indicators for atherosclerosis. The surface roughness of porcine coronary arteries have been detailed based on optical microscopy and implemented into a cylindrical section of coronary artery. Several approaches to rheology are compared to determine the benefits/limitations of both single and multiphase models for multi-scale geometry. Haemodynamic parameters averaged over the rough/smooth sections are similar; however, the rough surface experiences a much wider range, with maximum wall shear stress greater than 6 Pa compared to the approximately 3 Pa on the smooth segment. This suggests the smooth-walled assumption may neglect important near-wall haemodynamics. While rheological models lack sufficient definition to truly encompass the micro-scale effects occurring over the rough surface, single-phase models (Newtonian and non-Newtonian) provide numerically stable and comparable results to other coronary simulations. Multiphase models allow for phase interactions between plasma and red blood cells which is more suited to such multi-scale models. These models require additional physical laws to govern advection/aggregation of particulates in the near-wall region.
Details
Original language | English |
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Article number | 20200327 |
Journal | Journal of The Royal Society Interface |
Volume | 17 |
Issue number | 169 |
Early online date | 12 Aug 2020 |
Publication status | Published - 26 Aug 2020 |
Keywords
- computational fluid dynamics, coronary, multiphase, red blood cell migration, rheology, roughness