Arteriolar dysfunction is restored in ishaemic muscles by chronic electrical stimulation

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Arteriolar dysfunction is restored in ishaemic muscles by chronic electrical stimulation. / Kelsall, CJ; Brown, Margaret; Kent, Joyce; Kloehn, M; Hudlicka, Olga.

In: Journal of Vascular Research, Vol. 41, 01.01.2004, p. 241-251.

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Kelsall, CJ ; Brown, Margaret ; Kent, Joyce ; Kloehn, M ; Hudlicka, Olga. / Arteriolar dysfunction is restored in ishaemic muscles by chronic electrical stimulation. In: Journal of Vascular Research. 2004 ; Vol. 41. pp. 241-251.

Bibtex

@article{5e59434857d74c5aa4043ceec1e60f41,
title = "Arteriolar dysfunction is restored in ishaemic muscles by chronic electrical stimulation",
abstract = "Chronic intermittent electrical stimulation (15 min on, 85 min off, seven times per day) eliminated endothelial dysfunction of pre-capillary arterioles in ischaemic rat ankle flexor muscles. Responses to acetylcholine were restored from constriction to dilation, and the reduced dilation to bradykinin was corrected by 1 week of stimulation. Administration of the NOS inhibitor N-omega-nitro-Larginine for 1 week impaired arteriolar reactivity in a similar way to ischaemia, and dilator function was likewise restored by chronic stimulation. This suggests that nitric oxide production in the microcirculation is depressed by chronic ischaemia and that chronic electrical stimulation can specifically reverse this deficit. Stimulation applied to ischaemic muscles for 2 weeks also increased the numbers of microvessels immunostained for alpha-smooth muscle actin and the numbers of eNOS-positive microvessels and capillaries. These findings help to elucidate the mechanism of the beneficial effect of exercise in the treatment of peripheral vascular diseases by showing that muscle activity can improve both function and structural capacity of the microvasculature. Copyright (C) 2004 S. Karger AG, Basel.",
keywords = "arterial ligation, capillaries, nitric oxide synthase inhibition, arterioles, skeletal muscle",
author = "CJ Kelsall and Margaret Brown and Joyce Kent and M Kloehn and Olga Hudlicka",
year = "2004",
month = jan,
day = "1",
doi = "10.1159/000078301",
language = "English",
volume = "41",
pages = "241--251",
journal = "Journal of Vascular Research",
issn = "1018-1172",
publisher = "Karger",

}

RIS

TY - JOUR

T1 - Arteriolar dysfunction is restored in ishaemic muscles by chronic electrical stimulation

AU - Kelsall, CJ

AU - Brown, Margaret

AU - Kent, Joyce

AU - Kloehn, M

AU - Hudlicka, Olga

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Chronic intermittent electrical stimulation (15 min on, 85 min off, seven times per day) eliminated endothelial dysfunction of pre-capillary arterioles in ischaemic rat ankle flexor muscles. Responses to acetylcholine were restored from constriction to dilation, and the reduced dilation to bradykinin was corrected by 1 week of stimulation. Administration of the NOS inhibitor N-omega-nitro-Larginine for 1 week impaired arteriolar reactivity in a similar way to ischaemia, and dilator function was likewise restored by chronic stimulation. This suggests that nitric oxide production in the microcirculation is depressed by chronic ischaemia and that chronic electrical stimulation can specifically reverse this deficit. Stimulation applied to ischaemic muscles for 2 weeks also increased the numbers of microvessels immunostained for alpha-smooth muscle actin and the numbers of eNOS-positive microvessels and capillaries. These findings help to elucidate the mechanism of the beneficial effect of exercise in the treatment of peripheral vascular diseases by showing that muscle activity can improve both function and structural capacity of the microvasculature. Copyright (C) 2004 S. Karger AG, Basel.

AB - Chronic intermittent electrical stimulation (15 min on, 85 min off, seven times per day) eliminated endothelial dysfunction of pre-capillary arterioles in ischaemic rat ankle flexor muscles. Responses to acetylcholine were restored from constriction to dilation, and the reduced dilation to bradykinin was corrected by 1 week of stimulation. Administration of the NOS inhibitor N-omega-nitro-Larginine for 1 week impaired arteriolar reactivity in a similar way to ischaemia, and dilator function was likewise restored by chronic stimulation. This suggests that nitric oxide production in the microcirculation is depressed by chronic ischaemia and that chronic electrical stimulation can specifically reverse this deficit. Stimulation applied to ischaemic muscles for 2 weeks also increased the numbers of microvessels immunostained for alpha-smooth muscle actin and the numbers of eNOS-positive microvessels and capillaries. These findings help to elucidate the mechanism of the beneficial effect of exercise in the treatment of peripheral vascular diseases by showing that muscle activity can improve both function and structural capacity of the microvasculature. Copyright (C) 2004 S. Karger AG, Basel.

KW - arterial ligation

KW - capillaries

KW - nitric oxide synthase inhibition

KW - arterioles

KW - skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=2942716834&partnerID=8YFLogxK

U2 - 10.1159/000078301

DO - 10.1159/000078301

M3 - Article

C2 - 15118363

VL - 41

SP - 241

EP - 251

JO - Journal of Vascular Research

JF - Journal of Vascular Research

SN - 1018-1172

ER -