Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)

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Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT). / Romero Canelon, Isolda; Phoenix, Ben; Pitto-Barry, Anaïs; Tran, Johanna; Soldevila-Barreda, Joan J.; Kirby, Nigel; Green, Stuart; Sadler, Peter J.; Barry, Nicolas P.E.

In: Journal of Organometallic Chemistry, Vol. 796, 01.11.2015, p. 17-25.

Research output: Contribution to journalArticlepeer-review

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APA

Romero Canelon, I., Phoenix, B., Pitto-Barry, A., Tran, J., Soldevila-Barreda, J. J., Kirby, N., Green, S., Sadler, P. J., & Barry, N. P. E. (2015). Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT). Journal of Organometallic Chemistry, 796, 17-25. https://doi.org/10.1016/j.jorganchem.2015.05.011

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Author

Romero Canelon, Isolda ; Phoenix, Ben ; Pitto-Barry, Anaïs ; Tran, Johanna ; Soldevila-Barreda, Joan J. ; Kirby, Nigel ; Green, Stuart ; Sadler, Peter J. ; Barry, Nicolas P.E. / Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT). In: Journal of Organometallic Chemistry. 2015 ; Vol. 796. pp. 17-25.

Bibtex

@article{5d18db1f934848a9a76b04e60d1d870b,
title = "Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)",
abstract = "We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic{\textregistered} triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).",
keywords = "Arene ruthenium, Boron neutron capture therapy, Carborane, Micelles, Pluronic",
author = "{Romero Canelon}, Isolda and Ben Phoenix and Ana{\"i}s Pitto-Barry and Johanna Tran and Soldevila-Barreda, {Joan J.} and Nigel Kirby and Stuart Green and Sadler, {Peter J.} and Barry, {Nicolas P.E.}",
year = "2015",
month = nov,
day = "1",
doi = "10.1016/j.jorganchem.2015.05.011",
language = "English",
volume = "796",
pages = "17--25",
journal = "Journal of Organometallic Chemistry",
issn = "0022-328X",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)

AU - Romero Canelon, Isolda

AU - Phoenix, Ben

AU - Pitto-Barry, Anaïs

AU - Tran, Johanna

AU - Soldevila-Barreda, Joan J.

AU - Kirby, Nigel

AU - Green, Stuart

AU - Sadler, Peter J.

AU - Barry, Nicolas P.E.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).

AB - We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).

KW - Arene ruthenium

KW - Boron neutron capture therapy

KW - Carborane

KW - Micelles

KW - Pluronic

UR - http://www.scopus.com/inward/record.url?scp=84941600763&partnerID=8YFLogxK

U2 - 10.1016/j.jorganchem.2015.05.011

DO - 10.1016/j.jorganchem.2015.05.011

M3 - Article

AN - SCOPUS:84941600763

VL - 796

SP - 17

EP - 25

JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

SN - 0022-328X

ER -