Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)

Isolda Romero Canelon; Ben Phoenix; Anaïs Pitto-Barry; Johanna Tran; Joan J. Soldevila-Barreda; Nigel Kirby; Stuart Green; Peter J. Sadler; Nicolas P.E. Barry

doi:10.1016/j.jorganchem.2015.05.011

Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)

Isolda Romero Canelon, Ben Phoenix, Anaïs Pitto-Barry, Johanna Tran, Joan J. Soldevila-Barreda, Nigel Kirby, Stuart Green^*, Peter J. Sadler, Nicolas P.E. Barry

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic^® triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC₅₀ 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC₅₀ 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).

Original language	English
Pages (from-to)	17-25
Number of pages	9
Journal	Journal of Organometallic Chemistry
Volume	796
Early online date	18 May 2015
DOIs	https://doi.org/10.1016/j.jorganchem.2015.05.011
Publication status	Published - 1 Nov 2015

Keywords

Arene ruthenium
Boron neutron capture therapy
Carborane
Micelles
Pluronic

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)",

abstract = "We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic{\textregistered} triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).",

keywords = "Arene ruthenium, Boron neutron capture therapy, Carborane, Micelles, Pluronic",

author = "{Romero Canelon}, Isolda and Ben Phoenix and Ana{\"i}s Pitto-Barry and Johanna Tran and Soldevila-Barreda, {Joan J.} and Nigel Kirby and Stuart Green and Sadler, {Peter J.} and Barry, {Nicolas P.E.}",

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doi = "10.1016/j.jorganchem.2015.05.011",

language = "English",

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journal = "Journal of Organometallic Chemistry",

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TY - JOUR

T1 - Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)

AU - Romero Canelon, Isolda

AU - Phoenix, Ben

AU - Pitto-Barry, Anaïs

AU - Tran, Johanna

AU - Soldevila-Barreda, Joan J.

AU - Kirby, Nigel

AU - Green, Stuart

AU - Sadler, Peter J.

AU - Barry, Nicolas P.E.

PY - 2015/11/1

Y1 - 2015/11/1

N2 - We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).

AB - We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).

KW - Arene ruthenium

KW - Boron neutron capture therapy

KW - Carborane

KW - Micelles

KW - Pluronic

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U2 - 10.1016/j.jorganchem.2015.05.011

DO - 10.1016/j.jorganchem.2015.05.011

M3 - Article

AN - SCOPUS:84941600763

SN - 0022-328X

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SP - 17

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JO - Journal of Organometallic Chemistry

JF - Journal of Organometallic Chemistry

ER -

Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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