Arene ruthenium dithiolato-carborane complexes for boron neutron capture therapy (BNCT)

Research output: Contribution to journalArticlepeer-review

Authors

  • Anaïs Pitto-Barry
  • Johanna Tran
  • Joan J. Soldevila-Barreda
  • Nigel Kirby
  • Stuart Green
  • Peter J. Sadler
  • Nicolas P.E. Barry

Colleges, School and Institutes

External organisations

  • University of Warwick
  • Australian Synchrotron

Abstract

We report the effect of low-energy thermal neutron irradiation on the antiproliferative activities of a highly hydrophobic organometallic arene ruthenium dithiolato-carborane complex [Ru(p-cymene) (1,2-dicarba-closo-dodecarborane-1,2-dithiolato)] (1), and of its formulation in Pluronic® triblock copolymer P123 core-shell micelles (RuMs). Complex 1 was highly active, with and without neutron irradiation, towards human ovarian cancer cells (A2780; IC50 0.14 μM and 0.17 μM, respectively) and cisplatin-resistant human ovarian cancer cells (A2780cisR; IC50 0.05 and 0.13 μM, respectively). Complex 1 was particularly sensitive to neutron irradiation in A2780cisR cells (2.6 × more potent after irradiation compared to non-irradiation). Although less potent, the encapsulated complex 1 as RuMs nanoparticles resulted in higher cellular accumulation (2.5×), and was sensitive to neutron irradiation in A2780 cells (1.4× more potent upon irradiation compared to non-irradiation).

Details

Original languageEnglish
Pages (from-to)17-25
Number of pages9
JournalJournal of Organometallic Chemistry
Volume796
Early online date18 May 2015
Publication statusPublished - 1 Nov 2015

Keywords

  • Arene ruthenium, Boron neutron capture therapy, Carborane, Micelles, Pluronic

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