Aquaporins and Their Regulation after Spinal Cord Injury

Research output: Contribution to journalReview article

Authors

Colleges, School and Institutes

External organisations

  • Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK. amh776@student.bham.ac.uk.
  • Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, UK. a.c.conner@bham.ac.uk.
  • Aston University
  • Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, B15 2TT, UK. a.logan@bham.ac.uk.
  • Neuroscience and Ophthalmology, Institute of Inflammation and Ageing, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. z.ahmed.1@bham.ac.uk.

Abstract

After injury to the spinal cord, edema contributes to the underlying detrimental pathophysiological outcomes that lead to worsening of function. Several related membrane proteins called aquaporins (AQPs) regulate water movement in fluid transporting tissues including the spinal cord. Within the cord, AQP1, 4 and 9 contribute to spinal cord injury (SCI)-induced edema. AQP1, 4 and 9 are expressed in a variety of cells including astrocytes, neurons, ependymal cells, and endothelial cells. This review discusses some of the recent findings of the involvement of AQP in SCI and highlights the need for further study of these proteins to develop effective therapies to counteract the negative effects of SCI-induced edema.

Details

Original languageEnglish
Article number174
JournalCells
Volume7
Issue number10
Publication statusPublished - 18 Oct 2018

Keywords

  • aquaporin, edema, spinal cord injury, water channel