Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop

Research output: Contribution to journalArticlepeer-review

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Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop. / Buesen, Roland; Chorley, Brian N.; Da Silva Lima, Beatriz; Daston, George; Deferme, Lize; Ebbels, Timothy; Gant, Timothy W.; Goetz, Amber; Greally, John; Gribaldo, Laura; Hackermüller, Jörg; Hubesch, Bruno; Jennen, Danyel; Johnson, Kamin; Kanno, Jun; Kauffmann, Hans-Martin; Laffont, Madeleine; Mcmullen, Patrick; Meehan, Richard; Pemberton, Mark; Perdichizzi, Stefania; Piersma, Aldert H.; Sauer, Ursula G.; Schmidt, Kerstin; Seitz, Hervé; Sumida, Kayo; Tollefsen, Knut E.; Tong, Weida; Tralau, Tewes; Van Ravenzwaay, Ben; Weber, Ralf J.m.; Worth, Andrew; Yauk, Carole; Poole, Alan.

In: Regulatory Toxicology and Pharmacology, Vol. 91, No. Supplement 1, 01.12.2017, p. S3-S13.

Research output: Contribution to journalArticlepeer-review

Harvard

Buesen, R, Chorley, BN, Da Silva Lima, B, Daston, G, Deferme, L, Ebbels, T, Gant, TW, Goetz, A, Greally, J, Gribaldo, L, Hackermüller, J, Hubesch, B, Jennen, D, Johnson, K, Kanno, J, Kauffmann, H-M, Laffont, M, Mcmullen, P, Meehan, R, Pemberton, M, Perdichizzi, S, Piersma, AH, Sauer, UG, Schmidt, K, Seitz, H, Sumida, K, Tollefsen, KE, Tong, W, Tralau, T, Van Ravenzwaay, B, Weber, RJM, Worth, A, Yauk, C & Poole, A 2017, 'Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop', Regulatory Toxicology and Pharmacology, vol. 91, no. Supplement 1, pp. S3-S13. https://doi.org/10.1016/j.yrtph.2017.09.002

APA

Buesen, R., Chorley, B. N., Da Silva Lima, B., Daston, G., Deferme, L., Ebbels, T., Gant, T. W., Goetz, A., Greally, J., Gribaldo, L., Hackermüller, J., Hubesch, B., Jennen, D., Johnson, K., Kanno, J., Kauffmann, H-M., Laffont, M., Mcmullen, P., Meehan, R., ... Poole, A. (2017). Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regulatory Toxicology and Pharmacology, 91(Supplement 1), S3-S13. https://doi.org/10.1016/j.yrtph.2017.09.002

Vancouver

Buesen R, Chorley BN, Da Silva Lima B, Daston G, Deferme L, Ebbels T et al. Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop. Regulatory Toxicology and Pharmacology. 2017 Dec 1;91(Supplement 1):S3-S13. https://doi.org/10.1016/j.yrtph.2017.09.002

Author

Buesen, Roland ; Chorley, Brian N. ; Da Silva Lima, Beatriz ; Daston, George ; Deferme, Lize ; Ebbels, Timothy ; Gant, Timothy W. ; Goetz, Amber ; Greally, John ; Gribaldo, Laura ; Hackermüller, Jörg ; Hubesch, Bruno ; Jennen, Danyel ; Johnson, Kamin ; Kanno, Jun ; Kauffmann, Hans-Martin ; Laffont, Madeleine ; Mcmullen, Patrick ; Meehan, Richard ; Pemberton, Mark ; Perdichizzi, Stefania ; Piersma, Aldert H. ; Sauer, Ursula G. ; Schmidt, Kerstin ; Seitz, Hervé ; Sumida, Kayo ; Tollefsen, Knut E. ; Tong, Weida ; Tralau, Tewes ; Van Ravenzwaay, Ben ; Weber, Ralf J.m. ; Worth, Andrew ; Yauk, Carole ; Poole, Alan. / Applying 'omics technologies in chemicals risk assessment: Report of an ECETOC workshop. In: Regulatory Toxicology and Pharmacology. 2017 ; Vol. 91, No. Supplement 1. pp. S3-S13.

Bibtex

@article{167322447b374593818724eb42fe6d1d,
title = "Applying 'omics technologies in chemicals risk assessment:: Report of an ECETOC workshop",
abstract = "Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies in regulatory toxicology. Against this background, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop Applying 'omics technologies in chemicals risk assessment that is reported herein. Ahead of the workshop, multi-expert teams drafted frameworks on best practices for (i) a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) the processing of 'omics data; and (iii) weight-of-evidence approaches for integrating 'omics data. The workshop participants confirmed the relevance of these Frameworks to facilitate the regulatory applicability and use of 'omics data, and the workshop discussions provided input for their further elaboration. Additionally, the key objective (iv) to establish approaches to connect 'omics perturbations to phenotypic alterations was addressed. Generally, it was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways. While further work is necessary before gene expression changes can be used to establish safe levels of substance exposure, the ECETOC workshop provided important incentives towards achieving this goal.",
keywords = "regulatory toxicology , transcriptomics , metaboloics , good laboratory practice (GLP) , weight-of-evidence (WoE) , adverse outcome pathway (AOP) , mode-of-action (MoA) , gene expression , differentially expressed genes",
author = "Roland Buesen and Chorley, {Brian N.} and {Da Silva Lima}, Beatriz and George Daston and Lize Deferme and Timothy Ebbels and Gant, {Timothy W.} and Amber Goetz and John Greally and Laura Gribaldo and J{\"o}rg Hackerm{\"u}ller and Bruno Hubesch and Danyel Jennen and Kamin Johnson and Jun Kanno and Hans-Martin Kauffmann and Madeleine Laffont and Patrick Mcmullen and Richard Meehan and Mark Pemberton and Stefania Perdichizzi and Piersma, {Aldert H.} and Sauer, {Ursula G.} and Kerstin Schmidt and Herv{\'e} Seitz and Kayo Sumida and Tollefsen, {Knut E.} and Weida Tong and Tewes Tralau and {Van Ravenzwaay}, Ben and Weber, {Ralf J.m.} and Andrew Worth and Carole Yauk and Alan Poole",
year = "2017",
month = dec,
day = "1",
doi = "10.1016/j.yrtph.2017.09.002",
language = "English",
volume = "91",
pages = "S3--S13",
journal = "Regulatory Toxicology and Pharmacology",
issn = "0273-2300",
publisher = "Elsevier",
number = "Supplement 1",

}

RIS

TY - JOUR

T1 - Applying 'omics technologies in chemicals risk assessment:

T2 - Report of an ECETOC workshop

AU - Buesen, Roland

AU - Chorley, Brian N.

AU - Da Silva Lima, Beatriz

AU - Daston, George

AU - Deferme, Lize

AU - Ebbels, Timothy

AU - Gant, Timothy W.

AU - Goetz, Amber

AU - Greally, John

AU - Gribaldo, Laura

AU - Hackermüller, Jörg

AU - Hubesch, Bruno

AU - Jennen, Danyel

AU - Johnson, Kamin

AU - Kanno, Jun

AU - Kauffmann, Hans-Martin

AU - Laffont, Madeleine

AU - Mcmullen, Patrick

AU - Meehan, Richard

AU - Pemberton, Mark

AU - Perdichizzi, Stefania

AU - Piersma, Aldert H.

AU - Sauer, Ursula G.

AU - Schmidt, Kerstin

AU - Seitz, Hervé

AU - Sumida, Kayo

AU - Tollefsen, Knut E.

AU - Tong, Weida

AU - Tralau, Tewes

AU - Van Ravenzwaay, Ben

AU - Weber, Ralf J.m.

AU - Worth, Andrew

AU - Yauk, Carole

AU - Poole, Alan

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies in regulatory toxicology. Against this background, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop Applying 'omics technologies in chemicals risk assessment that is reported herein. Ahead of the workshop, multi-expert teams drafted frameworks on best practices for (i) a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) the processing of 'omics data; and (iii) weight-of-evidence approaches for integrating 'omics data. The workshop participants confirmed the relevance of these Frameworks to facilitate the regulatory applicability and use of 'omics data, and the workshop discussions provided input for their further elaboration. Additionally, the key objective (iv) to establish approaches to connect 'omics perturbations to phenotypic alterations was addressed. Generally, it was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways. While further work is necessary before gene expression changes can be used to establish safe levels of substance exposure, the ECETOC workshop provided important incentives towards achieving this goal.

AB - Prevailing knowledge gaps in linking specific molecular changes to apical outcomes and methodological uncertainties in the generation, storage, processing, and interpretation of 'omics data limit the application of 'omics technologies in regulatory toxicology. Against this background, the European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) convened a workshop Applying 'omics technologies in chemicals risk assessment that is reported herein. Ahead of the workshop, multi-expert teams drafted frameworks on best practices for (i) a Good-Laboratory Practice-like context for collecting, storing and curating 'omics data; (ii) the processing of 'omics data; and (iii) weight-of-evidence approaches for integrating 'omics data. The workshop participants confirmed the relevance of these Frameworks to facilitate the regulatory applicability and use of 'omics data, and the workshop discussions provided input for their further elaboration. Additionally, the key objective (iv) to establish approaches to connect 'omics perturbations to phenotypic alterations was addressed. Generally, it was considered promising to strive to link gene expression changes and pathway perturbations to the phenotype by mapping them to specific adverse outcome pathways. While further work is necessary before gene expression changes can be used to establish safe levels of substance exposure, the ECETOC workshop provided important incentives towards achieving this goal.

KW - regulatory toxicology

KW - transcriptomics

KW - metaboloics

KW - good laboratory practice (GLP)

KW - weight-of-evidence (WoE)

KW - adverse outcome pathway (AOP)

KW - mode-of-action (MoA)

KW - gene expression

KW - differentially expressed genes

U2 - 10.1016/j.yrtph.2017.09.002

DO - 10.1016/j.yrtph.2017.09.002

M3 - Article

VL - 91

SP - S3-S13

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

IS - Supplement 1

ER -