Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

Research output: Contribution to journalArticlepeer-review

Authors

  • Alessio De Simone
  • Gian Filippo Ruda
  • Clara Albani
  • Glauco Tarozzo
  • Tiziano Bandiera
  • Daniele Piomelli
  • Andrea Cavalli

Colleges, School and Institutes

External organisations

  • Istituto Italiano di Tecnologia
  • University of California, Irvine
  • Università di Bologna

Abstract

Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.

Details

Original languageEnglish
Pages (from-to)4904-4907
Number of pages4
JournalChemical Communications
Volume50
Issue number38
Early online date25 Mar 2014
Publication statusPublished - 18 May 2014