Applying a multitarget rational drug design strategy: the first set of modulators with potent and balanced activity toward dopamine D3 receptor and fatty acid amide hydrolase

Alessio De Simone, Gian Filippo Ruda, Clara Albani, Glauco Tarozzo, Tiziano Bandiera, Daniele Piomelli, Andrea Cavalli, Giovanni Bottegoni*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

Combining computer-assisted drug design and synthetic efforts, we generated compounds with potent and balanced activities toward both D3 dopamine receptor and fatty acid amide hydrolase (FAAH) enzyme. By concurrently modulating these targets, our compounds hold great potential toward exerting a disease-modifying effect on nicotine addiction and other forms of compulsive behavior.

Original languageEnglish
Pages (from-to)4904-4907
Number of pages4
JournalChemical Communications
Volume50
Issue number38
Early online date25 Mar 2014
DOIs
Publication statusPublished - 18 May 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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