Application of the Three Rs to challenge assays used in vaccine testing Tenth report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement

M Jennings; David Morton; E Charton; J Cooper; C Hendriksen; S Martin; MC Pearce; S Price; K Redhead; N Reed; H Simmons; S Spencer; H Willingale

doi:10.1016/j.biologicals.2010.04.004

Application of the Three Rs to challenge assays used in vaccine testing Tenth report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement

M Jennings, David Morton, E Charton, J Cooper, C Hendriksen, S Martin, MC Pearce, S Price, K Redhead, N Reed, H Simmons, S Spencer, H Willingale

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

This report alms to facilitate the implementation of the Three Rs (reduction refinement and replacement) in the testing of vaccines for regulatory and other purposes The focus is predominantly on identification of reduction and refinement opportunities in batch potency testing but the principles described are widely applicable to other situations that involve experimental infections of animals The report should also help to interpret the requirements of the European Pharmacopoeia with regard to the use of alternative tests humane endpoints and other refinements Two specific worked examples for batch potency testing of Clostridium chauvoei and canine leptospira with recommendations for harmonisation of international test requirements for these and other vaccines are provided as appendices online

Original language	English
Pages (from-to)	684-695
Number of pages	12
Journal	Biologicals
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.biologicals.2010.04.004
Publication status	Published - 1 Nov 2010

Keywords

Humane endpoints
Vaccines
Three Rs
Guideline harmonisation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.biologicals.2010.04.004

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Jennings, M., Morton, D., Charton, E., Cooper, J., Hendriksen, C., Martin, S., Pearce, MC., Price, S., Redhead, K., Reed, N., Simmons, H., Spencer, S., & Willingale, H. (2010). Application of the Three Rs to challenge assays used in vaccine testing Tenth report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement. Biologicals, 38(6), 684-695. https://doi.org/10.1016/j.biologicals.2010.04.004

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Jennings, M, Morton, D, Charton, E, Cooper, J, Hendriksen, C, Martin, S, Pearce, MC, Price, S, Redhead, K, Reed, N, Simmons, H, Spencer, S & Willingale, H 2010, 'Application of the Three Rs to challenge assays used in vaccine testing Tenth report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement', Biologicals, vol. 38, no. 6, pp. 684-695. https://doi.org/10.1016/j.biologicals.2010.04.004

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AU - Morton, David

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AU - Cooper, J

AU - Hendriksen, C

AU - Martin, S

AU - Pearce, MC

AU - Price, S

AU - Redhead, K

AU - Reed, N

AU - Simmons, H

AU - Spencer, S

AU - Willingale, H

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Application of the Three Rs to challenge assays used in vaccine testing Tenth report of the BVAAWF/FRAME/RSPCA/UFAW Joint Working Group on Refinement

Abstract

Keywords

UN SDGs

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