Application of nano-particle coatings to carrier particles using an integrated fluidized bed supercritical fluid precipitation process

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@article{a1cfd218c1794f27b5abc1d67adb2c57,
title = "Application of nano-particle coatings to carrier particles using an integrated fluidized bed supercritical fluid precipitation process",
abstract = "Production of active ingredients such as pharmaceuticals in nano-particulate form is highly desirable but the resulting product is difficult to handle and to use in applications. A novel process is described for coating nanoparticles onto excipient particles of c. 300 μm by rapid expansion of a supercritical solution (RESS) into two types of modified proprietary equipment: a Wurster coater and a fluidized bed. This novel approach has been demonstrated through the successful deposition of six mimics for active ingredients (benzoic acid, adamantane, ferrocene, phenanthrene, stearic acid and vitamin K3) on carrier excipient particles of microcrystalline cellulose (MCC). Evidence from SEM, EDX and Confocal Raman microscopy suggests that the coating particles are below 30 nm in size. Unlike most conventional coating processes, this approach avoids the use of liquids and high temperatures. As a wide range of actives and excipients can potentially be employed, the approach is applicable across the process and product industries, in particular pharmaceutical, household goods, personal care and catalyst industries.",
keywords = "Supercritical fluid, Fluidized bed, Wurster coater, Coating, Nano-particles, Excipient, Dosage form",
author = "Leeke, {Gary A.} and Tiejun Lu and Bridson, {Rachel H.} and Seville, {Jonathan P.k.}",
year = "2014",
month = jul,
day = "1",
doi = "10.1016/j.supflu.2014.03.012",
language = "English",
volume = "91",
pages = "7--14",
journal = "Journal of Supercritical Fluids",
issn = "0896-8446",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Application of nano-particle coatings to carrier particles using an integrated fluidized bed supercritical fluid precipitation process

AU - Leeke, Gary A.

AU - Lu, Tiejun

AU - Bridson, Rachel H.

AU - Seville, Jonathan P.k.

PY - 2014/7/1

Y1 - 2014/7/1

N2 - Production of active ingredients such as pharmaceuticals in nano-particulate form is highly desirable but the resulting product is difficult to handle and to use in applications. A novel process is described for coating nanoparticles onto excipient particles of c. 300 μm by rapid expansion of a supercritical solution (RESS) into two types of modified proprietary equipment: a Wurster coater and a fluidized bed. This novel approach has been demonstrated through the successful deposition of six mimics for active ingredients (benzoic acid, adamantane, ferrocene, phenanthrene, stearic acid and vitamin K3) on carrier excipient particles of microcrystalline cellulose (MCC). Evidence from SEM, EDX and Confocal Raman microscopy suggests that the coating particles are below 30 nm in size. Unlike most conventional coating processes, this approach avoids the use of liquids and high temperatures. As a wide range of actives and excipients can potentially be employed, the approach is applicable across the process and product industries, in particular pharmaceutical, household goods, personal care and catalyst industries.

AB - Production of active ingredients such as pharmaceuticals in nano-particulate form is highly desirable but the resulting product is difficult to handle and to use in applications. A novel process is described for coating nanoparticles onto excipient particles of c. 300 μm by rapid expansion of a supercritical solution (RESS) into two types of modified proprietary equipment: a Wurster coater and a fluidized bed. This novel approach has been demonstrated through the successful deposition of six mimics for active ingredients (benzoic acid, adamantane, ferrocene, phenanthrene, stearic acid and vitamin K3) on carrier excipient particles of microcrystalline cellulose (MCC). Evidence from SEM, EDX and Confocal Raman microscopy suggests that the coating particles are below 30 nm in size. Unlike most conventional coating processes, this approach avoids the use of liquids and high temperatures. As a wide range of actives and excipients can potentially be employed, the approach is applicable across the process and product industries, in particular pharmaceutical, household goods, personal care and catalyst industries.

KW - Supercritical fluid

KW - Fluidized bed

KW - Wurster coater

KW - Coating

KW - Nano-particles

KW - Excipient

KW - Dosage form

U2 - 10.1016/j.supflu.2014.03.012

DO - 10.1016/j.supflu.2014.03.012

M3 - Article

VL - 91

SP - 7

EP - 14

JO - Journal of Supercritical Fluids

JF - Journal of Supercritical Fluids

SN - 0896-8446

ER -