Apoptotic caspases in promoting cancer: implications from their roles in development and tissue homeostasis

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Apoptotic caspases in promoting cancer: implications from their roles in development and tissue homeostasis. / Dabrowska, Catherine; Li, MingLi; Fan, Yun.

In: Advances in Experimental Medicine and Biology, Vol. 930, 2016, p. 89-112.

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@article{656fedb2f0d643fa9db0a322e85573a9,
title = "Apoptotic caspases in promoting cancer: implications from their roles in development and tissue homeostasis",
abstract = "Apoptosis, a major form of programmed cell death, is an important mechanism to remove extra or unwanted cells during development. In tissue homeostasis apoptosis also acts as a monitoring machinery to eliminate damaged cells in response to environmental stresses. During these processes, caspases, a group of proteases, have been well defined as key drivers of cell death. However, a wealth of evidence is emerging which supports the existence of many other non-apoptotic functions of these caspases, which are essential not only in proper organism development but also in tissue homeostasis and post-injury recovery. In particular, apoptotic caspases in stress-induced dying cells can activate mitogenic signals leading to proliferation of neighbouring cells, a phenomenon termed apoptosis-induced proliferation. Apparently, such non-apoptotic functions of caspases need to be controlled and restrained in a context-dependent manner during development to prevent their detrimental effects. Intriguingly, accumulating studies suggest that cancer cells are able to utilise these functions of caspases to their advantage to enable their survival, proliferation and metastasis in order to grow and progress. This book chapter will review non-apoptotic functions of the caspases in development and tissue homeostasis with focus on how these cellular processes can be hijacked by cancer cells and contribute to tumourigenesis.",
author = "Catherine Dabrowska and MingLi Li and Yun Fan",
note = "Advances in Experimental Medicine and Biology. Title: Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities Editor: Christopher D. Gregory volume 930 ISSN: 0065-2598 ISBN: 978-3-319-39404-6, 978-3-319-39406-0 DOI: 10.1007/978-3-319-39406-0",
year = "2016",
doi = "10.1007/978-3-319-39406-0",
language = "English",
volume = "930",
pages = "89--112",
journal = "Advances in Experimental Medicine and Biology",
issn = "0065-2598",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Apoptotic caspases in promoting cancer: implications from their roles in development and tissue homeostasis

AU - Dabrowska, Catherine

AU - Li, MingLi

AU - Fan, Yun

N1 - Advances in Experimental Medicine and Biology. Title: Apoptosis in Cancer Pathogenesis and Anti-cancer Therapy: New Perspectives and Opportunities Editor: Christopher D. Gregory volume 930 ISSN: 0065-2598 ISBN: 978-3-319-39404-6, 978-3-319-39406-0 DOI: 10.1007/978-3-319-39406-0

PY - 2016

Y1 - 2016

N2 - Apoptosis, a major form of programmed cell death, is an important mechanism to remove extra or unwanted cells during development. In tissue homeostasis apoptosis also acts as a monitoring machinery to eliminate damaged cells in response to environmental stresses. During these processes, caspases, a group of proteases, have been well defined as key drivers of cell death. However, a wealth of evidence is emerging which supports the existence of many other non-apoptotic functions of these caspases, which are essential not only in proper organism development but also in tissue homeostasis and post-injury recovery. In particular, apoptotic caspases in stress-induced dying cells can activate mitogenic signals leading to proliferation of neighbouring cells, a phenomenon termed apoptosis-induced proliferation. Apparently, such non-apoptotic functions of caspases need to be controlled and restrained in a context-dependent manner during development to prevent their detrimental effects. Intriguingly, accumulating studies suggest that cancer cells are able to utilise these functions of caspases to their advantage to enable their survival, proliferation and metastasis in order to grow and progress. This book chapter will review non-apoptotic functions of the caspases in development and tissue homeostasis with focus on how these cellular processes can be hijacked by cancer cells and contribute to tumourigenesis.

AB - Apoptosis, a major form of programmed cell death, is an important mechanism to remove extra or unwanted cells during development. In tissue homeostasis apoptosis also acts as a monitoring machinery to eliminate damaged cells in response to environmental stresses. During these processes, caspases, a group of proteases, have been well defined as key drivers of cell death. However, a wealth of evidence is emerging which supports the existence of many other non-apoptotic functions of these caspases, which are essential not only in proper organism development but also in tissue homeostasis and post-injury recovery. In particular, apoptotic caspases in stress-induced dying cells can activate mitogenic signals leading to proliferation of neighbouring cells, a phenomenon termed apoptosis-induced proliferation. Apparently, such non-apoptotic functions of caspases need to be controlled and restrained in a context-dependent manner during development to prevent their detrimental effects. Intriguingly, accumulating studies suggest that cancer cells are able to utilise these functions of caspases to their advantage to enable their survival, proliferation and metastasis in order to grow and progress. This book chapter will review non-apoptotic functions of the caspases in development and tissue homeostasis with focus on how these cellular processes can be hijacked by cancer cells and contribute to tumourigenesis.

U2 - 10.1007/978-3-319-39406-0

DO - 10.1007/978-3-319-39406-0

M3 - Article

VL - 930

SP - 89

EP - 112

JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

SN - 0065-2598

ER -