Apolipoprotein E-epsilon 4 and recurrent genital herpes in individuals co-infected with herpes simplex virus type 2 and HIV.

Research output: Contribution to journalArticle


  • AN Jayasuriya
  • RF Itzhaki
  • MA Wozniak
  • R Patel
  • EJ Smit
  • R Noone
  • G Gilleran
  • DJ White

Colleges, School and Institutes


Apolipoprotein E (APOE) alleles have been associated with the severity of, or susceptibility to, infection by various microbes. We investigated the potential association between the APOE-epsilon 4 allele and the rate of recurrence of genital herpes in patients who were HIV positive and herpes simplex virus type 2 (HSV-2) seropositive. The APOE-epsilon 4 allele was significantly associated with recurrent genital ulceration independent of ethnicity, antiretroviral therapy and CD4 count (OR 8.3; 95% CI 2.4 to 28.5). To our knowledge, this is the first published study to demonstrate this association and suggests that APOE-epsilon 4 may represent a future prognostic marker for symptomatic recurrence of genital herpes in individuals with HIV.


Original languageEnglish
Pages (from-to)516-7
Number of pages2
JournalSexually Transmitted Infections
Issue number7
Publication statusPublished - 1 Dec 2008