Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial

Carlos J Montoya; Fabian Jaimes; Edwin A Higuita; Sandra Convers-Páez; Santiago Estrada; Francisco Gutierrez; Pedro Amariles; Newar Giraldo; Cristina Peñaloza; Maria T Rugeles; Tracy Roberts

doi:10.1186/1745-6215-10-41

Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial

Carlos J Montoya, Fabian Jaimes, Edwin A Higuita, Sandra Convers-Páez, Santiago Estrada, Francisco Gutierrez, Pedro Amariles, Newar Giraldo, Cristina Peñaloza, Maria T Rugeles, Tracy Roberts

Health Economics Unit

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Highly active antiretroviral therapy produces a significant decrease in HIV-1 replication and allows an increase in the CD4 T-cell count, leading to a decrease in the incidence of opportunistic infections and mortality. However, the cost, side effects and complexity of antiretroviral regimens have underscored the immediate need for additional therapeutic approaches. Statins exert pleiotropic effects through a variety of mechanisms, among which there are several immunoregulatory effects, related and unrelated to their cholesterol-lowering activity that can be useful to control HIV-1 infection.

Original language	English
Pages (from-to)	41
Journal	Trials
Volume	10
DOIs	https://doi.org/10.1186/1745-6215-10-41
Publication status	Published - 2009

Keywords

Anticholesteremic Agents
Antiretroviral Therapy, Highly Active
Antiviral Agents
HIV Infections
HIV-1
Humans
Lovastatin
Regression Analysis
Research Design

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1745-6215-10-41

Cite this

Montoya, C. J., Jaimes, F., Higuita, E. A., Convers-Páez, S., Estrada, S., Gutierrez, F., Amariles, P., Giraldo, N., Peñaloza, C., Rugeles, M. T., & Roberts, T. (2009). Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial. Trials, 10, 41. https://doi.org/10.1186/1745-6215-10-41

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title = "Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial",

abstract = "Highly active antiretroviral therapy produces a significant decrease in HIV-1 replication and allows an increase in the CD4 T-cell count, leading to a decrease in the incidence of opportunistic infections and mortality. However, the cost, side effects and complexity of antiretroviral regimens have underscored the immediate need for additional therapeutic approaches. Statins exert pleiotropic effects through a variety of mechanisms, among which there are several immunoregulatory effects, related and unrelated to their cholesterol-lowering activity that can be useful to control HIV-1 infection.",

keywords = "Anticholesteremic Agents, Antiretroviral Therapy, Highly Active, Antiviral Agents, HIV Infections, HIV-1, Humans, Lovastatin, Regression Analysis, Research Design",

author = "Montoya, {Carlos J} and Fabian Jaimes and Higuita, {Edwin A} and Sandra Convers-P{\'a}ez and Santiago Estrada and Francisco Gutierrez and Pedro Amariles and Newar Giraldo and Cristina Pe{\~n}aloza and Rugeles, {Maria T} and Tracy Roberts",

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doi = "10.1186/1745-6215-10-41",

language = "English",

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Montoya, CJ, Jaimes, F, Higuita, EA, Convers-Páez, S, Estrada, S, Gutierrez, F, Amariles, P, Giraldo, N, Peñaloza, C, Rugeles, MT & Roberts, T 2009, 'Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial', Trials, vol. 10, pp. 41. https://doi.org/10.1186/1745-6215-10-41

TY - JOUR

T1 - Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study)

T2 - a phase-II randomized clinical trial

AU - Montoya, Carlos J

AU - Jaimes, Fabian

AU - Higuita, Edwin A

AU - Convers-Páez, Sandra

AU - Estrada, Santiago

AU - Gutierrez, Francisco

AU - Amariles, Pedro

AU - Giraldo, Newar

AU - Peñaloza, Cristina

AU - Rugeles, Maria T

AU - Roberts, Tracy

PY - 2009

Y1 - 2009

N2 - Highly active antiretroviral therapy produces a significant decrease in HIV-1 replication and allows an increase in the CD4 T-cell count, leading to a decrease in the incidence of opportunistic infections and mortality. However, the cost, side effects and complexity of antiretroviral regimens have underscored the immediate need for additional therapeutic approaches. Statins exert pleiotropic effects through a variety of mechanisms, among which there are several immunoregulatory effects, related and unrelated to their cholesterol-lowering activity that can be useful to control HIV-1 infection.

AB - Highly active antiretroviral therapy produces a significant decrease in HIV-1 replication and allows an increase in the CD4 T-cell count, leading to a decrease in the incidence of opportunistic infections and mortality. However, the cost, side effects and complexity of antiretroviral regimens have underscored the immediate need for additional therapeutic approaches. Statins exert pleiotropic effects through a variety of mechanisms, among which there are several immunoregulatory effects, related and unrelated to their cholesterol-lowering activity that can be useful to control HIV-1 infection.

KW - Anticholesteremic Agents

KW - Antiretroviral Therapy, Highly Active

KW - Antiviral Agents

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Lovastatin

KW - Regression Analysis

KW - Research Design

U2 - 10.1186/1745-6215-10-41

DO - 10.1186/1745-6215-10-41

M3 - Article

C2 - 19538732

SN - 1745-6215

VL - 10

SP - 41

JO - Trials

JF - Trials

ER -

Antiretroviral effect of lovastatin on HIV-1-infected individuals without highly active antiretroviral therapy (The LIVE study): a phase-II randomized clinical trial

Abstract

Keywords

UN SDGs

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