Antioxidant Therapies in Traumatic Brain Injury

Research output: Contribution to journalReview articlepeer-review

Standard

Antioxidant Therapies in Traumatic Brain Injury. / Di Pietro, Valentina; Yakoub, Kamal M; Caruso, Giuseppe; Lazzarino, Giacomo; Signoretti, Stefano; Barbey, Aron K; Tavazzi, Barbara; Lazzarino, Giuseppe; Belli, Antonio; Amorini, Angela Maria.

In: Antioxidants, Vol. 9, No. 3, 22.03.2020.

Research output: Contribution to journalReview articlepeer-review

Harvard

Di Pietro, V, Yakoub, KM, Caruso, G, Lazzarino, G, Signoretti, S, Barbey, AK, Tavazzi, B, Lazzarino, G, Belli, A & Amorini, AM 2020, 'Antioxidant Therapies in Traumatic Brain Injury', Antioxidants, vol. 9, no. 3. https://doi.org/10.3390/antiox9030260

APA

Di Pietro, V., Yakoub, K. M., Caruso, G., Lazzarino, G., Signoretti, S., Barbey, A. K., Tavazzi, B., Lazzarino, G., Belli, A., & Amorini, A. M. (2020). Antioxidant Therapies in Traumatic Brain Injury. Antioxidants, 9(3). https://doi.org/10.3390/antiox9030260

Vancouver

Di Pietro V, Yakoub KM, Caruso G, Lazzarino G, Signoretti S, Barbey AK et al. Antioxidant Therapies in Traumatic Brain Injury. Antioxidants. 2020 Mar 22;9(3). https://doi.org/10.3390/antiox9030260

Author

Di Pietro, Valentina ; Yakoub, Kamal M ; Caruso, Giuseppe ; Lazzarino, Giacomo ; Signoretti, Stefano ; Barbey, Aron K ; Tavazzi, Barbara ; Lazzarino, Giuseppe ; Belli, Antonio ; Amorini, Angela Maria. / Antioxidant Therapies in Traumatic Brain Injury. In: Antioxidants. 2020 ; Vol. 9, No. 3.

Bibtex

@article{d4515141cfcd4f698a3d821f8457cf02,
title = "Antioxidant Therapies in Traumatic Brain Injury",
abstract = "Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly heterogeneous pathology, characterized by high mortality and disability rates. TBI is an acute neurodegenerative event, potentially and unpredictably evolving into sub-chronic and chronic neurodegenerative events, with transient or permanent neurologic, cognitive, and motor deficits, for which no valid standardized therapies are available. A vast body of literature demonstrates that TBI-induced oxidative/nitrosative stress is involved in the development of both acute and chronic neurodegenerative disorders. Cellular defenses against this phenomenon are largely dependent on low molecular weight antioxidants, most of which are consumed with diet or as nutraceutical supplements. A large number of studies have evaluated the efficacy of antioxidant administration to decrease TBI-associated damage in various animal TBI models and in a limited number of clinical trials. Points of weakness of preclinical studies are represented by the large variability in the TBI model adopted, in the antioxidant tested, in the timing, dosages, and routes of administration used, and in the variety of molecular and/or neurocognitive parameters evaluated. The analysis of the very few clinical studies does not allow strong conclusions to be drawn on the real effectiveness of antioxidant administration to TBI patients. Standardizing TBI models and different experimental conditions, as well as testing the efficacy of administration of a cocktail of antioxidants rather than only one, should be mandatory. According to some promising clinical results, it appears that sports-related concussion is probably the best type of TBI to test the benefits of antioxidant administration.",
author = "{Di Pietro}, Valentina and Yakoub, {Kamal M} and Giuseppe Caruso and Giacomo Lazzarino and Stefano Signoretti and Barbey, {Aron K} and Barbara Tavazzi and Giuseppe Lazzarino and Antonio Belli and Amorini, {Angela Maria}",
year = "2020",
month = mar,
day = "22",
doi = "10.3390/antiox9030260",
language = "English",
volume = "9",
journal = "Antioxidants",
issn = "2076-3921",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "3",

}

RIS

TY - JOUR

T1 - Antioxidant Therapies in Traumatic Brain Injury

AU - Di Pietro, Valentina

AU - Yakoub, Kamal M

AU - Caruso, Giuseppe

AU - Lazzarino, Giacomo

AU - Signoretti, Stefano

AU - Barbey, Aron K

AU - Tavazzi, Barbara

AU - Lazzarino, Giuseppe

AU - Belli, Antonio

AU - Amorini, Angela Maria

PY - 2020/3/22

Y1 - 2020/3/22

N2 - Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly heterogeneous pathology, characterized by high mortality and disability rates. TBI is an acute neurodegenerative event, potentially and unpredictably evolving into sub-chronic and chronic neurodegenerative events, with transient or permanent neurologic, cognitive, and motor deficits, for which no valid standardized therapies are available. A vast body of literature demonstrates that TBI-induced oxidative/nitrosative stress is involved in the development of both acute and chronic neurodegenerative disorders. Cellular defenses against this phenomenon are largely dependent on low molecular weight antioxidants, most of which are consumed with diet or as nutraceutical supplements. A large number of studies have evaluated the efficacy of antioxidant administration to decrease TBI-associated damage in various animal TBI models and in a limited number of clinical trials. Points of weakness of preclinical studies are represented by the large variability in the TBI model adopted, in the antioxidant tested, in the timing, dosages, and routes of administration used, and in the variety of molecular and/or neurocognitive parameters evaluated. The analysis of the very few clinical studies does not allow strong conclusions to be drawn on the real effectiveness of antioxidant administration to TBI patients. Standardizing TBI models and different experimental conditions, as well as testing the efficacy of administration of a cocktail of antioxidants rather than only one, should be mandatory. According to some promising clinical results, it appears that sports-related concussion is probably the best type of TBI to test the benefits of antioxidant administration.

AB - Due to a multiplicity of causes provoking traumatic brain injury (TBI), TBI is a highly heterogeneous pathology, characterized by high mortality and disability rates. TBI is an acute neurodegenerative event, potentially and unpredictably evolving into sub-chronic and chronic neurodegenerative events, with transient or permanent neurologic, cognitive, and motor deficits, for which no valid standardized therapies are available. A vast body of literature demonstrates that TBI-induced oxidative/nitrosative stress is involved in the development of both acute and chronic neurodegenerative disorders. Cellular defenses against this phenomenon are largely dependent on low molecular weight antioxidants, most of which are consumed with diet or as nutraceutical supplements. A large number of studies have evaluated the efficacy of antioxidant administration to decrease TBI-associated damage in various animal TBI models and in a limited number of clinical trials. Points of weakness of preclinical studies are represented by the large variability in the TBI model adopted, in the antioxidant tested, in the timing, dosages, and routes of administration used, and in the variety of molecular and/or neurocognitive parameters evaluated. The analysis of the very few clinical studies does not allow strong conclusions to be drawn on the real effectiveness of antioxidant administration to TBI patients. Standardizing TBI models and different experimental conditions, as well as testing the efficacy of administration of a cocktail of antioxidants rather than only one, should be mandatory. According to some promising clinical results, it appears that sports-related concussion is probably the best type of TBI to test the benefits of antioxidant administration.

U2 - 10.3390/antiox9030260

DO - 10.3390/antiox9030260

M3 - Review article

C2 - 32235799

VL - 9

JO - Antioxidants

JF - Antioxidants

SN - 2076-3921

IS - 3

ER -