Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces

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@article{e1a13ae8b06c4f939998f902a7fb8a26,
title = "Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces",
abstract = "The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material–tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs. The dual approach gives an efficacious coating which is stable for over 12 months and can prevent colonization of the surface by both Gram-positive and Gram-negative bacteria.",
keywords = "surface engineering, device–tissue interface, antimicrobial",
author = "Leigh Townsend and Richard Williams and Olachi Anuforom and Matthew Berwick and Fenella Halstead and Erik Hughes and Artemis Stamboulis and Beryl Oppenheim and Gough, {Julie E.} and Liam Grover and Robert Scott and Mark Webber and Anna Peacock and Antonio Belli and Ann Logan and {De Cogan}, Felicity",
year = "2017",
month = "1",
day = "31",
doi = "10.1098/rsif.2016.0657",
language = "English",
volume = "14",
pages = "1--12",
journal = "Journal of The Royal Society Interface",
issn = "1742-5689",
publisher = "The Royal Society",
number = "126",

}

RIS

TY - JOUR

T1 - Antimicrobial peptide coatings for hydroxyapatite

T2 - electrostatic and covalent attachment of antimicrobial peptides to surfaces

AU - Townsend, Leigh

AU - Williams, Richard

AU - Anuforom, Olachi

AU - Berwick, Matthew

AU - Halstead, Fenella

AU - Hughes, Erik

AU - Stamboulis, Artemis

AU - Oppenheim, Beryl

AU - Gough, Julie E.

AU - Grover, Liam

AU - Scott, Robert

AU - Webber, Mark

AU - Peacock, Anna

AU - Belli, Antonio

AU - Logan, Ann

AU - De Cogan, Felicity

PY - 2017/1/31

Y1 - 2017/1/31

N2 - The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material–tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs. The dual approach gives an efficacious coating which is stable for over 12 months and can prevent colonization of the surface by both Gram-positive and Gram-negative bacteria.

AB - The interface between implanted devices and their host tissue is complex and is often optimized for maximal integration and cell adhesion. However, this also gives a surface suitable for bacterial colonization. We have developed a novel method of modifying the surface at the material–tissue interface with an antimicrobial peptide (AMP) coating to allow cell attachment while inhibiting bacterial colonization. The technology reported here is a dual AMP coating. The dual coating consists of AMPs covalently bonded to the hydroxyapatite surface, followed by deposition of electrostatically bound AMPs. The dual approach gives an efficacious coating which is stable for over 12 months and can prevent colonization of the surface by both Gram-positive and Gram-negative bacteria.

KW - surface engineering

KW - device–tissue interface

KW - antimicrobial

UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310730/

UR - https://europepmc.org/article/MED/28077764

U2 - 10.1098/rsif.2016.0657

DO - 10.1098/rsif.2016.0657

M3 - Article

VL - 14

SP - 1

EP - 12

JO - Journal of The Royal Society Interface

JF - Journal of The Royal Society Interface

SN - 1742-5689

IS - 126

M1 - 20160657

ER -