Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

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Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. / Walker, Lucy; Chodos, A; Eggena, M; Dooms, H; Abbas, AK.

In: The Journal of Experimental Medicine, Vol. 198, 21.07.2003, p. 249-58.

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Walker, Lucy ; Chodos, A ; Eggena, M ; Dooms, H ; Abbas, AK. / Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo. In: The Journal of Experimental Medicine. 2003 ; Vol. 198. pp. 249-58.

Bibtex

@article{0926e2a68b584a879d4c9106e32ed771,
title = "Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo",
abstract = "The failure of CD25+ regulatory T cells (Tregs) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use Tregs expressing a transgenic TCR to show that despite anergy in vitro, Tregs proliferate in response to immunization in vivo. Tregs also proliferate and accumulate locally in response to transgenically expressed tissue antigen whereas their CD25- counterparts are depleted at such sites. Collectively, these data suggest that the anergic state that characterizes CD25+ Tregs in vitro may not accurately reflect their responsiveness in vivo. These observations support a model in which Treg population dynamics are shaped by the local antigenic environment.",
keywords = "regulatory T cells, autoantigen, peripheral tolerance, CD4(+) T lymphocytes, autoimmunity",
author = "Lucy Walker and A Chodos and M Eggena and H Dooms and AK Abbas",
year = "2003",
month = jul,
day = "21",
doi = "10.1084/jem.20030315",
language = "English",
volume = "198",
pages = "249--58",
journal = "The Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",

}

RIS

TY - JOUR

T1 - Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo

AU - Walker, Lucy

AU - Chodos, A

AU - Eggena, M

AU - Dooms, H

AU - Abbas, AK

PY - 2003/7/21

Y1 - 2003/7/21

N2 - The failure of CD25+ regulatory T cells (Tregs) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use Tregs expressing a transgenic TCR to show that despite anergy in vitro, Tregs proliferate in response to immunization in vivo. Tregs also proliferate and accumulate locally in response to transgenically expressed tissue antigen whereas their CD25- counterparts are depleted at such sites. Collectively, these data suggest that the anergic state that characterizes CD25+ Tregs in vitro may not accurately reflect their responsiveness in vivo. These observations support a model in which Treg population dynamics are shaped by the local antigenic environment.

AB - The failure of CD25+ regulatory T cells (Tregs) to proliferate after T cell receptor (TCR) stimulation in vitro has lead to their classification as naturally anergic. Here we use Tregs expressing a transgenic TCR to show that despite anergy in vitro, Tregs proliferate in response to immunization in vivo. Tregs also proliferate and accumulate locally in response to transgenically expressed tissue antigen whereas their CD25- counterparts are depleted at such sites. Collectively, these data suggest that the anergic state that characterizes CD25+ Tregs in vitro may not accurately reflect their responsiveness in vivo. These observations support a model in which Treg population dynamics are shaped by the local antigenic environment.

KW - regulatory T cells

KW - autoantigen

KW - peripheral tolerance

KW - CD4(+) T lymphocytes

KW - autoimmunity

UR - http://www.scopus.com/inward/record.url?scp=0043244867&partnerID=8YFLogxK

U2 - 10.1084/jem.20030315

DO - 10.1084/jem.20030315

M3 - Article

C2 - 12874258

VL - 198

SP - 249

EP - 258

JO - The Journal of Experimental Medicine

JF - The Journal of Experimental Medicine

SN - 0022-1007

ER -