Antibody response to vaccination and psychological stress in humans Relationships and mechanisms

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Antibody response to vaccination and psychological stress in humans Relationships and mechanisms. / Burns, Victoria; Carroll, Douglas; Ring, Christopher; Drayson, Mark.

In: Vaccine, Vol. 21, No. 19-20, 01.06.2003, p. 2523-2534.

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@article{e017b7843bfa4e5ba735f3ac09170ff4,
title = "Antibody response to vaccination and psychological stress in humans Relationships and mechanisms",
abstract = "The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymus-dependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.",
keywords = "psychosocial stress, psychoneuroimmunology, antibody response to immunisation",
author = "Victoria Burns and Douglas Carroll and Christopher Ring and Mark Drayson",
year = "2003",
month = jun,
day = "1",
doi = "10.1016/S0264-410X(03)00041-0",
language = "English",
volume = "21",
pages = "2523--2534",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier",
number = "19-20",

}

RIS

TY - JOUR

T1 - Antibody response to vaccination and psychological stress in humans Relationships and mechanisms

AU - Burns, Victoria

AU - Carroll, Douglas

AU - Ring, Christopher

AU - Drayson, Mark

PY - 2003/6/1

Y1 - 2003/6/1

N2 - The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymus-dependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.

AB - The purpose of this review is to determine the effects of psychosocial stress on antibody response to vaccination in humans, consider possible mechanisms, and identify agenda for future research. Studies of the association between stress and vaccination response in humans were reviewed. There is evidence of a negative association between stress and antibody response to vaccination, which is most apparent with thymus-dependent vaccines and when measured at extended times after vaccination. Preliminary findings implicate the hypothalamic-pituitary-adrenal axis and sympathetic nervous system as potential mechanisms, although a role for unhealthy behaviours cannot be discounted at this stage. Results to date are sufficiently indicative to direct future research to untangling their theoretical ramifications, as well as realising their clinical implications.

KW - psychosocial stress

KW - psychoneuroimmunology

KW - antibody response to immunisation

UR - http://www.scopus.com/inward/record.url?scp=0038064457&partnerID=8YFLogxK

U2 - 10.1016/S0264-410X(03)00041-0

DO - 10.1016/S0264-410X(03)00041-0

M3 - Article

C2 - 12744887

VL - 21

SP - 2523

EP - 2534

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 19-20

ER -