Antibodies to protein P in systemic lupus erythematosus
Research output: Contribution to journal › Article › peer-review
Authors
Colleges, School and Institutes
Abstract
A synthetic peptide was used to develop an enzyme linked immunosorbent assay (ELISA) to detect antibodies to the ribosomal proteins P0, P1, and P2. Significantly increased levels of IgG antibodies to protein P were found in 16% (18/116) of patients with systemic lupus erythematosus but slightly increased levels were detected in 2% (2/98) of patients with rheumatoid arthritis and one normal control subject. No association was observed between the presence of IgG antibodies to protein P and either lupus psychosis or depression. Sequential studies in individual patients failed to show an association between antibody levels and the development of psychosis.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 489-94 |
| Number of pages | 6 |
| Journal | Annals of the Rheumatic Diseases |
| Volume | 51 |
| Issue number | 4 |
| Publication status | Published - Apr 1992 |
Keywords
- Antibodies, Antibodies, Antinuclear, Antibody Specificity, Arthritis, Rheumatoid, Blotting, Western, Enzyme-Linked Immunosorbent Assay, Humans, Immunoglobulin G, Lupus Erythematosus, Systemic, Mental Disorders, Nervous System Diseases, Phosphoproteins, Ribosomal Proteins