Anti-basal ganglia antibodies and Tourette's syndrome: a voxel-based morphometry and diffusion tensor imaging study in an adult population

D Martino, B Draganski, Andrea Cavanna, A Church, G Defazio, MM Robertson, RSJ Frackowiak, G Giovannoni, HD Critchley

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Anti-basal ganglia antibodies (ABGAs) have been suggested to be a hallmark of autoimmunity in Gilles de la Tourette's syndrome (GTS), possibly related to prior exposure to streptococcal infection. In order to detect whether the presence of ABGAs was associated with subtle structural changes in GTS, whole-brain analysis using independent sets of T(1) and diffusion tensor imaging MRI-based methods were performed on 22 adults with GTS with (n = 9) and without (n = 13) detectable ABGAs in the serum. Voxel-based morphometry analysis failed to detect any significant difference in grey matter density between ABGA-positive and ABGA-negative groups in caudate nuclei, putamina, thalami and frontal lobes. These results suggest that ABGA synthesis is not related to structural changes in grey and white matter (detectable with these methods) within frontostriatal circuits.
Original languageEnglish
Pages (from-to)820-822
Number of pages3
JournalJournal of Neurology Neurosurgery and Psychiatry
Volume79
Issue number7
DOIs
Publication statusPublished - 1 Jul 2008

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