Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

Research output: Contribution to journalArticle

Standard

Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. / Steffen, A; Schulze, MB; Pischon, T; Dietrich, Thomas; Molina, E; Chirlaque, MD; Barricarte, A; Amiano, P; Quiros, JR; Tumino, R; Mattiello, A; Palli, D; Vineis, P; Agnoli, C; Misirli, G; Boffetta, P; Kaaks, R; Rohrmann, S; Bueno-de-Mesquita, HB; Peeters, PHM; May, AM; Spencer, EA; Allen, NE; Bingham, S; Tjonneland, A; Halkjaer, J; Overvad, K; Stegger, J; Manjer, J; Lindkvist, B; Hallmanns, G; Stenling, R; Lund, E; Riboli, E; Gonzalez, CA; Boeing, H.

In: Cancer Epidemiology Biomarkers &amp Prevention, Vol. 18, No. 7, 01.07.2009, p. 2079-2089.

Research output: Contribution to journalArticle

Harvard

Steffen, A, Schulze, MB, Pischon, T, Dietrich, T, Molina, E, Chirlaque, MD, Barricarte, A, Amiano, P, Quiros, JR, Tumino, R, Mattiello, A, Palli, D, Vineis, P, Agnoli, C, Misirli, G, Boffetta, P, Kaaks, R, Rohrmann, S, Bueno-de-Mesquita, HB, Peeters, PHM, May, AM, Spencer, EA, Allen, NE, Bingham, S, Tjonneland, A, Halkjaer, J, Overvad, K, Stegger, J, Manjer, J, Lindkvist, B, Hallmanns, G, Stenling, R, Lund, E, Riboli, E, Gonzalez, CA & Boeing, H 2009, 'Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition', Cancer Epidemiology Biomarkers &amp Prevention, vol. 18, no. 7, pp. 2079-2089. https://doi.org/10.1158/1055-9965.EPI-09-0265

APA

Steffen, A., Schulze, MB., Pischon, T., Dietrich, T., Molina, E., Chirlaque, MD., Barricarte, A., Amiano, P., Quiros, JR., Tumino, R., Mattiello, A., Palli, D., Vineis, P., Agnoli, C., Misirli, G., Boffetta, P., Kaaks, R., Rohrmann, S., Bueno-de-Mesquita, HB., ... Boeing, H. (2009). Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. Cancer Epidemiology Biomarkers &amp Prevention, 18(7), 2079-2089. https://doi.org/10.1158/1055-9965.EPI-09-0265

Vancouver

Author

Steffen, A ; Schulze, MB ; Pischon, T ; Dietrich, Thomas ; Molina, E ; Chirlaque, MD ; Barricarte, A ; Amiano, P ; Quiros, JR ; Tumino, R ; Mattiello, A ; Palli, D ; Vineis, P ; Agnoli, C ; Misirli, G ; Boffetta, P ; Kaaks, R ; Rohrmann, S ; Bueno-de-Mesquita, HB ; Peeters, PHM ; May, AM ; Spencer, EA ; Allen, NE ; Bingham, S ; Tjonneland, A ; Halkjaer, J ; Overvad, K ; Stegger, J ; Manjer, J ; Lindkvist, B ; Hallmanns, G ; Stenling, R ; Lund, E ; Riboli, E ; Gonzalez, CA ; Boeing, H. / Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition. In: Cancer Epidemiology Biomarkers &amp Prevention. 2009 ; Vol. 18, No. 7. pp. 2079-2089.

Bibtex

@article{fbb02581c45d4e5fa7d2c6b512446d84,
title = "Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition",
abstract = "Background: Increasing evidence suggests that general obesity [measured by body mass index (BMI)] is positively associated with risk of esophageal adenocarcinoma (EAC). In contrast, previous studies have shown inverse relations with esophageal squamous cell carcinoma (ESCC). However, it is still unclear whether body fat distribution, particularly abdominal obesity, is associated with each type of esophageal cancer. Methods: We applied multivariable adjusted Cox proportional hazards regression to investigate the association between anthropometric measures and risk of EAC and ESCC among 346,554 men and women participating in the European Prospective Investigation into Cancer and Nutrition. All statistical tests were two sided. Results: During 8.9 years of follow-up, we documented 88 incident cases of EAC and 110 cases of ESCC. BMI, waist circumference, and waist-to-hip ratio (WHR) were positively associated with EAC risk [highest versus lowest quintile; relative risk (RR), 2.60; 95% confidence interval (95% CI), 1.23-5.51; P-trend <0.01; RR, 3.07; 95% CI, 1.35-6.98; P-trend <0.003; and RR, 2.12; 95% CI, 0.98-4.57; P-trend <0.004]. In contrast, BMI and waist circumference were inversely related to ESCC risk, whereas WHR showed no association with ESCC. In stratified analyses, BMI and waist circumference were significantly inversely related to ESCC only among smokers but not among nonsmokers. However, when controlled for BMI, we found positive associations for waist circumference and WHR with ESCC, and these associations were observed among smokers and nonsmokers. Conclusion: General and abdominal obesity were associated with higher EAC risk. Further, our study suggests that particularly an abdominal body fat distribution might also be a risk factor for ESCC. (Cancer Epidemiol Biomarkers Prev 2009;18(7):2079-89)",
author = "A Steffen and MB Schulze and T Pischon and Thomas Dietrich and E Molina and MD Chirlaque and A Barricarte and P Amiano and JR Quiros and R Tumino and A Mattiello and D Palli and P Vineis and C Agnoli and G Misirli and P Boffetta and R Kaaks and S Rohrmann and HB Bueno-de-Mesquita and PHM Peeters and AM May and EA Spencer and NE Allen and S Bingham and A Tjonneland and J Halkjaer and K Overvad and J Stegger and J Manjer and B Lindkvist and G Hallmanns and R Stenling and E Lund and E Riboli and CA Gonzalez and H Boeing",
year = "2009",
month = jul,
day = "1",
doi = "10.1158/1055-9965.EPI-09-0265",
language = "English",
volume = "18",
pages = "2079--2089",
journal = "Cancer Epidemiology, Biomarkers & Prevention",
issn = "1055-9965",
publisher = "American Association for Cancer Research",
number = "7",

}

RIS

TY - JOUR

T1 - Anthropometry and Esophageal Cancer Risk in the European Prospective Investigation into Cancer and Nutrition

AU - Steffen, A

AU - Schulze, MB

AU - Pischon, T

AU - Dietrich, Thomas

AU - Molina, E

AU - Chirlaque, MD

AU - Barricarte, A

AU - Amiano, P

AU - Quiros, JR

AU - Tumino, R

AU - Mattiello, A

AU - Palli, D

AU - Vineis, P

AU - Agnoli, C

AU - Misirli, G

AU - Boffetta, P

AU - Kaaks, R

AU - Rohrmann, S

AU - Bueno-de-Mesquita, HB

AU - Peeters, PHM

AU - May, AM

AU - Spencer, EA

AU - Allen, NE

AU - Bingham, S

AU - Tjonneland, A

AU - Halkjaer, J

AU - Overvad, K

AU - Stegger, J

AU - Manjer, J

AU - Lindkvist, B

AU - Hallmanns, G

AU - Stenling, R

AU - Lund, E

AU - Riboli, E

AU - Gonzalez, CA

AU - Boeing, H

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Background: Increasing evidence suggests that general obesity [measured by body mass index (BMI)] is positively associated with risk of esophageal adenocarcinoma (EAC). In contrast, previous studies have shown inverse relations with esophageal squamous cell carcinoma (ESCC). However, it is still unclear whether body fat distribution, particularly abdominal obesity, is associated with each type of esophageal cancer. Methods: We applied multivariable adjusted Cox proportional hazards regression to investigate the association between anthropometric measures and risk of EAC and ESCC among 346,554 men and women participating in the European Prospective Investigation into Cancer and Nutrition. All statistical tests were two sided. Results: During 8.9 years of follow-up, we documented 88 incident cases of EAC and 110 cases of ESCC. BMI, waist circumference, and waist-to-hip ratio (WHR) were positively associated with EAC risk [highest versus lowest quintile; relative risk (RR), 2.60; 95% confidence interval (95% CI), 1.23-5.51; P-trend <0.01; RR, 3.07; 95% CI, 1.35-6.98; P-trend <0.003; and RR, 2.12; 95% CI, 0.98-4.57; P-trend <0.004]. In contrast, BMI and waist circumference were inversely related to ESCC risk, whereas WHR showed no association with ESCC. In stratified analyses, BMI and waist circumference were significantly inversely related to ESCC only among smokers but not among nonsmokers. However, when controlled for BMI, we found positive associations for waist circumference and WHR with ESCC, and these associations were observed among smokers and nonsmokers. Conclusion: General and abdominal obesity were associated with higher EAC risk. Further, our study suggests that particularly an abdominal body fat distribution might also be a risk factor for ESCC. (Cancer Epidemiol Biomarkers Prev 2009;18(7):2079-89)

AB - Background: Increasing evidence suggests that general obesity [measured by body mass index (BMI)] is positively associated with risk of esophageal adenocarcinoma (EAC). In contrast, previous studies have shown inverse relations with esophageal squamous cell carcinoma (ESCC). However, it is still unclear whether body fat distribution, particularly abdominal obesity, is associated with each type of esophageal cancer. Methods: We applied multivariable adjusted Cox proportional hazards regression to investigate the association between anthropometric measures and risk of EAC and ESCC among 346,554 men and women participating in the European Prospective Investigation into Cancer and Nutrition. All statistical tests were two sided. Results: During 8.9 years of follow-up, we documented 88 incident cases of EAC and 110 cases of ESCC. BMI, waist circumference, and waist-to-hip ratio (WHR) were positively associated with EAC risk [highest versus lowest quintile; relative risk (RR), 2.60; 95% confidence interval (95% CI), 1.23-5.51; P-trend <0.01; RR, 3.07; 95% CI, 1.35-6.98; P-trend <0.003; and RR, 2.12; 95% CI, 0.98-4.57; P-trend <0.004]. In contrast, BMI and waist circumference were inversely related to ESCC risk, whereas WHR showed no association with ESCC. In stratified analyses, BMI and waist circumference were significantly inversely related to ESCC only among smokers but not among nonsmokers. However, when controlled for BMI, we found positive associations for waist circumference and WHR with ESCC, and these associations were observed among smokers and nonsmokers. Conclusion: General and abdominal obesity were associated with higher EAC risk. Further, our study suggests that particularly an abdominal body fat distribution might also be a risk factor for ESCC. (Cancer Epidemiol Biomarkers Prev 2009;18(7):2079-89)

U2 - 10.1158/1055-9965.EPI-09-0265

DO - 10.1158/1055-9965.EPI-09-0265

M3 - Article

C2 - 19567501

VL - 18

SP - 2079

EP - 2089

JO - Cancer Epidemiology, Biomarkers & Prevention

JF - Cancer Epidemiology, Biomarkers & Prevention

SN - 1055-9965

IS - 7

ER -