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Abstract
A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.
Original language | English |
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Pages (from-to) | 273-277 |
Number of pages | 5 |
Journal | Supramolecular Chemistry |
Volume | 23 |
Issue number | 3-4 |
Early online date | 13 Apr 2011 |
DOIs | |
Publication status | Published - 2011 |
Keywords
- sensor
- fluorescence
- anthracene
- SNP
- DNA
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Dive into the research topics of 'Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches'. Together they form a unique fingerprint.Projects
- 1 Finished
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Functional DNA-based assemblies
Engineering & Physical Science Research Council
16/03/09 → 31/03/14
Project: Research Councils