Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.

Details

Original languageEnglish
Pages (from-to)273-277
Number of pages5
JournalSupramolecular Chemistry
Volume23
Issue number3-4
Early online date13 Apr 2011
Publication statusPublished - 2011

Keywords

  • sensor, fluorescence, anthracene, SNP, DNA