Anthracene-modified oligonucleotides as fluorescent DNA mismatch sensors: discrimination between various base-pair mismatches
Research output: Contribution to journal › Article
Authors
Colleges, School and Institutes
Abstract
A fluorescent anthracene-tagged DNA probe has been shown to respond to various DNA sequences by changes to its emission signal upon duplex formation. The fluorescence response for duplexes containing a single mismatch near the anthracene site has been found to be very sensitive to its composition, with the emission signal increasing for a CA mismatch and decreasing for CT and CC mismatches.
Details
| Original language | English |
|---|---|
| Pages (from-to) | 273-277 |
| Number of pages | 5 |
| Journal | Supramolecular Chemistry |
| Volume | 23 |
| Issue number | 3-4 |
| Early online date | 13 Apr 2011 |
| Publication status | Published - 2011 |
Keywords
- sensor, fluorescence, anthracene, SNP, DNA