Animal models of retinal injury.

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Animal models of retinal injury. / Blanch, Richard; Ahmed, Zubair; Berry, Martin; Scott, Robert; Logan, Ann.

In: Investigative Ophthalmology & Visual Science (IOVS), Vol. 53, No. 6, 01.01.2012, p. 2913-20.

Research output: Contribution to journalArticle

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Blanch, Richard ; Ahmed, Zubair ; Berry, Martin ; Scott, Robert ; Logan, Ann. / Animal models of retinal injury. In: Investigative Ophthalmology & Visual Science (IOVS). 2012 ; Vol. 53, No. 6. pp. 2913-20.

Bibtex

@article{80dddae2549442e3a96cc1738045f572,
title = "Animal models of retinal injury.",
abstract = "Retinal injury is a common cause of profound and intractable loss of vision. Clinical outcomes are poor in both open and closed globe injuries because cell death, scarring, and a failure of tissue and axon regeneration are not ameliorated by current treatments. Much animal research is directed at understanding and modifying these pathologies, although results have yet to translate into clinical practice. Axotomy-induced retinal ganglion cell (RGC) death in mammals can be effectively reduced and axon regeneration enhanced over the short term. After retinal injury in mammals, the retinal pigment epithelium (RPE) and retinal glia either regenerate lost RPE and neuroretinal cells or form nonfunctional scars. An understanding of the mechanisms underlying injury responses is critical to the successful development of therapeutic strategies to promote ocular repair.",
author = "Richard Blanch and Zubair Ahmed and Martin Berry and Robert Scott and Ann Logan",
year = "2012",
month = jan,
day = "1",
doi = "10.1167/iovs.11-8564",
language = "English",
volume = "53",
pages = "2913--20",
journal = "Investigative Ophthalmology & Visual Science (IOVS)",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology",
number = "6",

}

RIS

TY - JOUR

T1 - Animal models of retinal injury.

AU - Blanch, Richard

AU - Ahmed, Zubair

AU - Berry, Martin

AU - Scott, Robert

AU - Logan, Ann

PY - 2012/1/1

Y1 - 2012/1/1

N2 - Retinal injury is a common cause of profound and intractable loss of vision. Clinical outcomes are poor in both open and closed globe injuries because cell death, scarring, and a failure of tissue and axon regeneration are not ameliorated by current treatments. Much animal research is directed at understanding and modifying these pathologies, although results have yet to translate into clinical practice. Axotomy-induced retinal ganglion cell (RGC) death in mammals can be effectively reduced and axon regeneration enhanced over the short term. After retinal injury in mammals, the retinal pigment epithelium (RPE) and retinal glia either regenerate lost RPE and neuroretinal cells or form nonfunctional scars. An understanding of the mechanisms underlying injury responses is critical to the successful development of therapeutic strategies to promote ocular repair.

AB - Retinal injury is a common cause of profound and intractable loss of vision. Clinical outcomes are poor in both open and closed globe injuries because cell death, scarring, and a failure of tissue and axon regeneration are not ameliorated by current treatments. Much animal research is directed at understanding and modifying these pathologies, although results have yet to translate into clinical practice. Axotomy-induced retinal ganglion cell (RGC) death in mammals can be effectively reduced and axon regeneration enhanced over the short term. After retinal injury in mammals, the retinal pigment epithelium (RPE) and retinal glia either regenerate lost RPE and neuroretinal cells or form nonfunctional scars. An understanding of the mechanisms underlying injury responses is critical to the successful development of therapeutic strategies to promote ocular repair.

U2 - 10.1167/iovs.11-8564

DO - 10.1167/iovs.11-8564

M3 - Article

C2 - 22603978

VL - 53

SP - 2913

EP - 2920

JO - Investigative Ophthalmology & Visual Science (IOVS)

JF - Investigative Ophthalmology & Visual Science (IOVS)

SN - 0146-0404

IS - 6

ER -