Animal models of GWAS-identified type 2 diabetes genes

Gabriela da Silva Xavier; Elisa A Bellomo; James A McGinty; Paul M French; Guy A Rutter

doi:10.1155/2013/906590

Animal models of GWAS-identified type 2 diabetes genes

Gabriela da Silva Xavier, Elisa A Bellomo, James A McGinty, Paul M French, Guy A Rutter

Metabolism and Systems Research

Research output: Contribution to journal › Review article › peer-review

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Abstract

More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.

Original language	English
Pages (from-to)	906590
Number of pages	12
Journal	Journal of Diabetes Research
Volume	2013
DOIs	https://doi.org/10.1155/2013/906590
Publication status	Published - 2013

Keywords

Animals
Diabetes Mellitus, Type 2/genetics
Disease Models, Animal
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Gabriela_da_Silva_Xavier_Animal_Models_of_GWAS-Identified_Type_2_Diabetes_Genes_Journal_of_Diabetes_Research_2013
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Cite this

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title = "Animal models of GWAS-identified type 2 diabetes genes",

abstract = "More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.",

keywords = "Animals, Diabetes Mellitus, Type 2/genetics, Disease Models, Animal, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide",

author = "{da Silva Xavier}, Gabriela and Bellomo, {Elisa A} and McGinty, {James A} and French, {Paul M} and Rutter, {Guy A}",

year = "2013",

doi = "10.1155/2013/906590",

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journal = "Journal of Diabetes Research",

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TY - JOUR

T1 - Animal models of GWAS-identified type 2 diabetes genes

AU - da Silva Xavier, Gabriela

AU - Bellomo, Elisa A

AU - McGinty, James A

AU - French, Paul M

AU - Rutter, Guy A

PY - 2013

Y1 - 2013

N2 - More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.

AB - More than 65 loci, encoding up to 500 different genes, have been implicated by genome-wide association studies (GWAS) as conferring an increased risk of developing type 2 diabetes (T2D). Whilst mouse models have in the past been central to understanding the mechanisms through which more penetrant risk genes for T2D, for example, those responsible for neonatal or maturity-onset diabetes of the young, only a few of those identified by GWAS, notably TCF7L2 and ZnT8/SLC30A8, have to date been examined in mouse models. We discuss here the animal models available for the latter genes and provide perspectives for future, higher throughput approaches towards efficiently mining the information provided by human genetics.

KW - Animals

KW - Diabetes Mellitus, Type 2/genetics

KW - Disease Models, Animal

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Humans

KW - Polymorphism, Single Nucleotide

U2 - 10.1155/2013/906590

DO - 10.1155/2013/906590

M3 - Review article

C2 - 23710470

SN - 2314-6745

VL - 2013

SP - 906590

JO - Journal of Diabetes Research

JF - Journal of Diabetes Research

ER -

Animal models of GWAS-identified type 2 diabetes genes

Abstract

Keywords

UN SDGs

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