TY - JOUR
T1 - Angiopoietin-2 levels as a biomarker of cardiovascular risk in patients with hypertension
AU - Patel, Jeetesh
AU - Lim, Hoong
AU - Varughese, GI
AU - Hughes, Elizabeth
AU - Lip, Gregory
PY - 2008/1/1
Y1 - 2008/1/1
N2 - BACKGROUND: Abnormal angiogenesis is a pathophysiological component of cardiovascular disease (CVD), where circulating biomarkers of angiogenesis are associated with increased CVD risk in hypertension. We hypothesized that raised levels of angiopoietin (Ang)-1 and -2 would predict events in patients with hypertension treated for CVD. METHODS: We measured angiopoietin levels by enzyme-linked immunosorbent assay (ELISA) in 251 hypertensive participants (85% male; mean age 63.5 years; 192 free of previous CVD events). Plasma angiopoietin levels were related to the subsequent CVD events over a mean follow-up period of 57.1 (SD 11) months. RESULTS: There were 11 cases of myocardial infarction (MI) and 18 cases of stroke during follow-up. Ang-2 was a significant predictor of MI, stroke, and composite CVD events, with the greatest event-free survival amongst those in the lower tertile (all P4.3 ng/mL optimized specificity and sensitivity. On Cox regression analysis (CVD treatments and risk factors), raised Ang-2 was an independent predictor of MI, P
AB - BACKGROUND: Abnormal angiogenesis is a pathophysiological component of cardiovascular disease (CVD), where circulating biomarkers of angiogenesis are associated with increased CVD risk in hypertension. We hypothesized that raised levels of angiopoietin (Ang)-1 and -2 would predict events in patients with hypertension treated for CVD. METHODS: We measured angiopoietin levels by enzyme-linked immunosorbent assay (ELISA) in 251 hypertensive participants (85% male; mean age 63.5 years; 192 free of previous CVD events). Plasma angiopoietin levels were related to the subsequent CVD events over a mean follow-up period of 57.1 (SD 11) months. RESULTS: There were 11 cases of myocardial infarction (MI) and 18 cases of stroke during follow-up. Ang-2 was a significant predictor of MI, stroke, and composite CVD events, with the greatest event-free survival amongst those in the lower tertile (all P4.3 ng/mL optimized specificity and sensitivity. On Cox regression analysis (CVD treatments and risk factors), raised Ang-2 was an independent predictor of MI, P
U2 - 10.1080/07853890701779586
DO - 10.1080/07853890701779586
M3 - Article
C2 - 18382887
SN - 1742-1241
VL - 40
SP - 215
EP - 222
JO - International Journal of Clinical Practice
JF - International Journal of Clinical Practice
IS - 3
ER -
