Angiogenic factors in atrial fibrillation: a possible role in thrombogenesis?

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Angiogenic factors in atrial fibrillation: a possible role in thrombogenesis? / Freestone, Bethan; Chong, AY; Lim, Hoong; Blann, A; Lip, Gregory.

In: Annals of Medicine, Vol. 37, No. 5, 01.01.2005, p. 365-72.

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Freestone, Bethan ; Chong, AY ; Lim, Hoong ; Blann, A ; Lip, Gregory. / Angiogenic factors in atrial fibrillation: a possible role in thrombogenesis?. In: Annals of Medicine. 2005 ; Vol. 37, No. 5. pp. 365-72.

Bibtex

@article{d00ccd56c399478f870327bf1d2d614a,
title = "Angiogenic factors in atrial fibrillation: a possible role in thrombogenesis?",
abstract = "BACKGROUND: The precise pathophysiological processes underlying the prothrombotic or hypercoagulable state in atrial fibrillation (AF) remain uncertain. We hypothesized a relationship between abnormal endothelial damage/dysfunction, coagulation, and angiogenic factors, thereby contributing to increased thrombogenicity. METHODS: Plasma levels of von Willebrand factor (vWF, an index of endothelial damage/dysfunction) and tissue factor (TF, an index of coagulation), as well as the angiogenic factors, vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), were measured by enzyme-linked immunosorbant assay (ELISA) in 59 chronic AF patients. Data were compared to 40 age- and sex-matched healthy controls in sinus rhythm. RESULTS: Plasma vWF, VEGF and Ang-2 were significantly higher in AF patients compared to healthy controls (P=0.005, P=0.0055 and P",
keywords = "angiopoietin, endothelium, vascular endothelial growth factor, tissue factor",
author = "Bethan Freestone and AY Chong and Hoong Lim and A Blann and Gregory Lip",
year = "2005",
month = jan,
day = "1",
doi = "10.1080/07853890510037392",
language = "English",
volume = "37",
pages = "365--72",
journal = "Annals of Medicine",
issn = "0785-3890",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Angiogenic factors in atrial fibrillation: a possible role in thrombogenesis?

AU - Freestone, Bethan

AU - Chong, AY

AU - Lim, Hoong

AU - Blann, A

AU - Lip, Gregory

PY - 2005/1/1

Y1 - 2005/1/1

N2 - BACKGROUND: The precise pathophysiological processes underlying the prothrombotic or hypercoagulable state in atrial fibrillation (AF) remain uncertain. We hypothesized a relationship between abnormal endothelial damage/dysfunction, coagulation, and angiogenic factors, thereby contributing to increased thrombogenicity. METHODS: Plasma levels of von Willebrand factor (vWF, an index of endothelial damage/dysfunction) and tissue factor (TF, an index of coagulation), as well as the angiogenic factors, vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), were measured by enzyme-linked immunosorbant assay (ELISA) in 59 chronic AF patients. Data were compared to 40 age- and sex-matched healthy controls in sinus rhythm. RESULTS: Plasma vWF, VEGF and Ang-2 were significantly higher in AF patients compared to healthy controls (P=0.005, P=0.0055 and P

AB - BACKGROUND: The precise pathophysiological processes underlying the prothrombotic or hypercoagulable state in atrial fibrillation (AF) remain uncertain. We hypothesized a relationship between abnormal endothelial damage/dysfunction, coagulation, and angiogenic factors, thereby contributing to increased thrombogenicity. METHODS: Plasma levels of von Willebrand factor (vWF, an index of endothelial damage/dysfunction) and tissue factor (TF, an index of coagulation), as well as the angiogenic factors, vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), were measured by enzyme-linked immunosorbant assay (ELISA) in 59 chronic AF patients. Data were compared to 40 age- and sex-matched healthy controls in sinus rhythm. RESULTS: Plasma vWF, VEGF and Ang-2 were significantly higher in AF patients compared to healthy controls (P=0.005, P=0.0055 and P

KW - angiopoietin

KW - endothelium

KW - vascular endothelial growth factor

KW - tissue factor

U2 - 10.1080/07853890510037392

DO - 10.1080/07853890510037392

M3 - Article

C2 - 16179272

VL - 37

SP - 365

EP - 372

JO - Annals of Medicine

JF - Annals of Medicine

SN - 0785-3890

IS - 5

ER -