Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease

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Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease. / Chung, Natali; Lydakis, C; Belgore, Funmilayo; Li Saw Hee, FL; Blann, Andrew; Lip, Gregory.

In: Heart, Vol. 89, No. 12, 01.12.2003, p. 1411-1415.

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Chung, Natali ; Lydakis, C ; Belgore, Funmilayo ; Li Saw Hee, FL ; Blann, Andrew ; Lip, Gregory. / Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease. In: Heart. 2003 ; Vol. 89, No. 12. pp. 1411-1415.

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@article{978508babe004dca9525d339ad57f5be,
title = "Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease",
abstract = "BACKGROUND: Thrombogenesis, angiogenesis, and endothelial damage/dysfunction are components in the pathogenesis of atherosclerosis. OBJECTIVE: To investigate the relation of these variables to atherosclerotic disease severity and the possible interrelations between the three. METHODS: 111 patients attending for coronary angiography were studied (85 male, 26 female; mean (SD) age, 61.6 (10.0) years). Plasma concentrations of von Willebrand factor (vWf, a marker of endothelial damage/dysfunction), vascular endothelial growth factor (VEGF, associated with angiogenesis), soluble VEGF receptor Flt-1 (sFlt-1), and tissue factor (TF, a key component of coagulation) were measured by an enzyme linked immunosorbent assay. Following angiography, disease severity was assessed by the number of coronary vessels diseased (> 50% stenosis) and by a coronary atheroma score. RESULTS: All indices were raised in the patients compared with 34 healthy controls except sFlt-1, which was lower in the patients. No significant correlations were found between the coronary atheroma score and values of vWf (Spearman correlations: r = 0.21, p = 0.83), VEGF (r = 0.11, p = 0.27), or TF (r = -0.04, p = 0.68). However, there was an inverse correlation between plasma sFlt-1 and coronary atheroma score (r = -0.19, p = 0.049). The number of vessels diseased had no relation to any marker. Correlations were found between TF and VEGF (r = 0.25, p = 0.008) and between TF and sFlt-1 (r = 0.42, p <0.001) in the patients. CONCLUSIONS: Despite evidence of abnormal angiogenesis (VEGF and sFlt-1), thrombogenesis (TF), and endothelial damage/dysfunction (vWf) in the patients with coronary artery disease, there was no correlation between VEGF, sFlt-1, vWf, or TF and angiographically defined disease severity.",
author = "Natali Chung and C Lydakis and Funmilayo Belgore and {Li Saw Hee}, FL and Andrew Blann and Gregory Lip",
year = "2003",
month = dec,
day = "1",
doi = "10.1136/heart.89.12.1411",
language = "English",
volume = "89",
pages = "1411--1415",
journal = "Heart",
issn = "1355-6037",
publisher = "BMJ Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease

AU - Chung, Natali

AU - Lydakis, C

AU - Belgore, Funmilayo

AU - Li Saw Hee, FL

AU - Blann, Andrew

AU - Lip, Gregory

PY - 2003/12/1

Y1 - 2003/12/1

N2 - BACKGROUND: Thrombogenesis, angiogenesis, and endothelial damage/dysfunction are components in the pathogenesis of atherosclerosis. OBJECTIVE: To investigate the relation of these variables to atherosclerotic disease severity and the possible interrelations between the three. METHODS: 111 patients attending for coronary angiography were studied (85 male, 26 female; mean (SD) age, 61.6 (10.0) years). Plasma concentrations of von Willebrand factor (vWf, a marker of endothelial damage/dysfunction), vascular endothelial growth factor (VEGF, associated with angiogenesis), soluble VEGF receptor Flt-1 (sFlt-1), and tissue factor (TF, a key component of coagulation) were measured by an enzyme linked immunosorbent assay. Following angiography, disease severity was assessed by the number of coronary vessels diseased (> 50% stenosis) and by a coronary atheroma score. RESULTS: All indices were raised in the patients compared with 34 healthy controls except sFlt-1, which was lower in the patients. No significant correlations were found between the coronary atheroma score and values of vWf (Spearman correlations: r = 0.21, p = 0.83), VEGF (r = 0.11, p = 0.27), or TF (r = -0.04, p = 0.68). However, there was an inverse correlation between plasma sFlt-1 and coronary atheroma score (r = -0.19, p = 0.049). The number of vessels diseased had no relation to any marker. Correlations were found between TF and VEGF (r = 0.25, p = 0.008) and between TF and sFlt-1 (r = 0.42, p <0.001) in the patients. CONCLUSIONS: Despite evidence of abnormal angiogenesis (VEGF and sFlt-1), thrombogenesis (TF), and endothelial damage/dysfunction (vWf) in the patients with coronary artery disease, there was no correlation between VEGF, sFlt-1, vWf, or TF and angiographically defined disease severity.

AB - BACKGROUND: Thrombogenesis, angiogenesis, and endothelial damage/dysfunction are components in the pathogenesis of atherosclerosis. OBJECTIVE: To investigate the relation of these variables to atherosclerotic disease severity and the possible interrelations between the three. METHODS: 111 patients attending for coronary angiography were studied (85 male, 26 female; mean (SD) age, 61.6 (10.0) years). Plasma concentrations of von Willebrand factor (vWf, a marker of endothelial damage/dysfunction), vascular endothelial growth factor (VEGF, associated with angiogenesis), soluble VEGF receptor Flt-1 (sFlt-1), and tissue factor (TF, a key component of coagulation) were measured by an enzyme linked immunosorbent assay. Following angiography, disease severity was assessed by the number of coronary vessels diseased (> 50% stenosis) and by a coronary atheroma score. RESULTS: All indices were raised in the patients compared with 34 healthy controls except sFlt-1, which was lower in the patients. No significant correlations were found between the coronary atheroma score and values of vWf (Spearman correlations: r = 0.21, p = 0.83), VEGF (r = 0.11, p = 0.27), or TF (r = -0.04, p = 0.68). However, there was an inverse correlation between plasma sFlt-1 and coronary atheroma score (r = -0.19, p = 0.049). The number of vessels diseased had no relation to any marker. Correlations were found between TF and VEGF (r = 0.25, p = 0.008) and between TF and sFlt-1 (r = 0.42, p <0.001) in the patients. CONCLUSIONS: Despite evidence of abnormal angiogenesis (VEGF and sFlt-1), thrombogenesis (TF), and endothelial damage/dysfunction (vWf) in the patients with coronary artery disease, there was no correlation between VEGF, sFlt-1, vWf, or TF and angiographically defined disease severity.

UR - http://www.scopus.com/inward/record.url?scp=0344825994&partnerID=8YFLogxK

U2 - 10.1136/heart.89.12.1411

DO - 10.1136/heart.89.12.1411

M3 - Article

C2 - 14617549

VL - 89

SP - 1411

EP - 1415

JO - Heart

JF - Heart

SN - 1355-6037

IS - 12

ER -