Analysis on Efficacy of Chitosan-Based Gel on Bone Quality and Quantity

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Analysis on Efficacy of Chitosan-Based Gel on Bone Quality and Quantity. / Jayash, Soher Nagi; Hashim, Najihah Mohd; Misran, Misni; Ibrahim, Norliza; Al-namnam, Nisreen Mohammed; Baharuddin, N. A.

In: Frontiers in Materials, Vol. 8, 640950, 30.03.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Jayash, SN, Hashim, NM, Misran, M, Ibrahim, N, Al-namnam, NM & Baharuddin, NA 2021, 'Analysis on Efficacy of Chitosan-Based Gel on Bone Quality and Quantity', Frontiers in Materials, vol. 8, 640950. https://doi.org/10.3389/fmats.2021.640950

APA

Jayash, S. N., Hashim, N. M., Misran, M., Ibrahim, N., Al-namnam, N. M., & Baharuddin, N. A. (2021). Analysis on Efficacy of Chitosan-Based Gel on Bone Quality and Quantity. Frontiers in Materials, 8, [640950]. https://doi.org/10.3389/fmats.2021.640950

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Author

Jayash, Soher Nagi ; Hashim, Najihah Mohd ; Misran, Misni ; Ibrahim, Norliza ; Al-namnam, Nisreen Mohammed ; Baharuddin, N. A. / Analysis on Efficacy of Chitosan-Based Gel on Bone Quality and Quantity. In: Frontiers in Materials. 2021 ; Vol. 8.

Bibtex

@article{2650f717d8fc458b9bebd85834874ee8,
title = "Analysis on Efficacy of Chitosan-Based Gel on Bone Quality and Quantity",
abstract = "Objectives: To assess and compare the quantity and the quality of the newly bone generated when using chitosan-based gel scaffold and osteoprotegerin-chitosan gel scaffold.Methods: A total of 18 critical-sized defects on New Zealand white rabbit craniums were created. In 12 defects, either chitosan gel or osteoprotegerin-chitosan gel was implanted the last six defects were kept unfilled as a control. Bone formation was examined at 6 and 12 weeks. Bone{\textquoteright}s specimens were scanned using the High-resolution peripheral quantitative computed tomography. Histological and histomorphometric analysis were carried out to compare the volume and area of regenerated bone.Results: The results of the HR-pQCT showed that bone volume and densities in the osteoprotegerin-chitosan gel group were significantly higher than the chitosan gel and control groups whereas, the bone volume density in the chitosan gel group was significantly higher than the control group in both intervals time (p = 0.01, p = 000). No significant difference in bone volume between the chitosan gel and control groups (p = 0.506, p = 0.640) was observed. However, similar findings were shown in the histomorphometric analysis, with the highest new bone formation was observed in the OPG-chitosan gel group followed by the chitosan group. The mean percentage of new bone was greater at 12 weeks compared to 6 weeks in all groups.Conclusions: Chitosan-based gel demonstrated a significant bone quantity and quality compared to unfilled surgical defects. Consistently, osteoprotegerin enhanced the chitosan gel in bone regeneration.",
author = "Jayash, {Soher Nagi} and Hashim, {Najihah Mohd} and Misni Misran and Norliza Ibrahim and Al-namnam, {Nisreen Mohammed} and Baharuddin, {N. A.}",
year = "2021",
month = mar,
day = "30",
doi = "10.3389/fmats.2021.640950",
language = "English",
volume = "8",
journal = "Frontiers in Materials",
issn = "2296-8016",
publisher = "Frontiers",

}

RIS

TY - JOUR

T1 - Analysis on Efficacy of Chitosan-Based Gel on Bone Quality and Quantity

AU - Jayash, Soher Nagi

AU - Hashim, Najihah Mohd

AU - Misran, Misni

AU - Ibrahim, Norliza

AU - Al-namnam, Nisreen Mohammed

AU - Baharuddin, N. A.

PY - 2021/3/30

Y1 - 2021/3/30

N2 - Objectives: To assess and compare the quantity and the quality of the newly bone generated when using chitosan-based gel scaffold and osteoprotegerin-chitosan gel scaffold.Methods: A total of 18 critical-sized defects on New Zealand white rabbit craniums were created. In 12 defects, either chitosan gel or osteoprotegerin-chitosan gel was implanted the last six defects were kept unfilled as a control. Bone formation was examined at 6 and 12 weeks. Bone’s specimens were scanned using the High-resolution peripheral quantitative computed tomography. Histological and histomorphometric analysis were carried out to compare the volume and area of regenerated bone.Results: The results of the HR-pQCT showed that bone volume and densities in the osteoprotegerin-chitosan gel group were significantly higher than the chitosan gel and control groups whereas, the bone volume density in the chitosan gel group was significantly higher than the control group in both intervals time (p = 0.01, p = 000). No significant difference in bone volume between the chitosan gel and control groups (p = 0.506, p = 0.640) was observed. However, similar findings were shown in the histomorphometric analysis, with the highest new bone formation was observed in the OPG-chitosan gel group followed by the chitosan group. The mean percentage of new bone was greater at 12 weeks compared to 6 weeks in all groups.Conclusions: Chitosan-based gel demonstrated a significant bone quantity and quality compared to unfilled surgical defects. Consistently, osteoprotegerin enhanced the chitosan gel in bone regeneration.

AB - Objectives: To assess and compare the quantity and the quality of the newly bone generated when using chitosan-based gel scaffold and osteoprotegerin-chitosan gel scaffold.Methods: A total of 18 critical-sized defects on New Zealand white rabbit craniums were created. In 12 defects, either chitosan gel or osteoprotegerin-chitosan gel was implanted the last six defects were kept unfilled as a control. Bone formation was examined at 6 and 12 weeks. Bone’s specimens were scanned using the High-resolution peripheral quantitative computed tomography. Histological and histomorphometric analysis were carried out to compare the volume and area of regenerated bone.Results: The results of the HR-pQCT showed that bone volume and densities in the osteoprotegerin-chitosan gel group were significantly higher than the chitosan gel and control groups whereas, the bone volume density in the chitosan gel group was significantly higher than the control group in both intervals time (p = 0.01, p = 000). No significant difference in bone volume between the chitosan gel and control groups (p = 0.506, p = 0.640) was observed. However, similar findings were shown in the histomorphometric analysis, with the highest new bone formation was observed in the OPG-chitosan gel group followed by the chitosan group. The mean percentage of new bone was greater at 12 weeks compared to 6 weeks in all groups.Conclusions: Chitosan-based gel demonstrated a significant bone quantity and quality compared to unfilled surgical defects. Consistently, osteoprotegerin enhanced the chitosan gel in bone regeneration.

U2 - 10.3389/fmats.2021.640950

DO - 10.3389/fmats.2021.640950

M3 - Article

VL - 8

JO - Frontiers in Materials

JF - Frontiers in Materials

SN - 2296-8016

M1 - 640950

ER -