Analysis of mechanisms of activation and repression at bacterial promoters.

Research output: Contribution to journalArticle

Colleges, School and Institutes

Abstract

In bacteria, the expression of transcription units is controlled by regulatory regions, that contain one or more promoters and binding sites for regulatory proteins that activate or repress expression in response to different signals. In this chapter, we explain the diverse approaches that can be used to understand the mechanisms by which the different factors intervene, and how the effects are integrated. Bioinformatics, genetics and biochemistry must be combined to understand the organisation of regulatory regions and the mechanisms by which transcription initiation is controlled.

Details

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalMethods
Volume47
Issue number1
Publication statusPublished - 1 Jan 2009

Keywords

  • Promoters, Genetics, Bacteria, Biochemistry, RNA polymerase, Activators, Regulation, Bioinformatics, Repressors