Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process

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@article{a36a9972a4fc4aed9e668468a64f763c,
title = "Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process",
abstract = "Dry powder formulations with potential application in pulmonary drug delivery were produced by integrating the Supercritical Antisolvent (SAS) process with a fluidized bed (FB) under pressure. The simultaneous precipitation and coating of curcumin on lactose was performed in a single step combining the advantages of both processes. Ethanol and acetone were used as solvents. The effects of operating parameters: pressure, temperature, drug-lactose mass ratio, solution flow rate and solution concentration on the drug size, morphology and yield were investigated. Due to the high degree of mixing in the fluidized bed, a uniform coating of curcumin onto lactose was achieved with loading efficiency varying from 71.0 to 93.3% and curcumin particle size between 0.41 and 12.08 μm. Solvent-free curcumin particles with reduced crystallinity were produced while the physicochemical properties of the raw materials were not changed.",
keywords = "Coating, Curcumin, Fluidized bed, Lactose, Pulmonary delivery, Supercritical antisolvent",
author = "{Lessa Matos}, Ravenna and Tiejun Lu and Christopher McConville and Gary Leeke and Andy Ingram",
year = "2018",
month = nov,
day = "1",
doi = "10.1016/j.supflu.2017.12.013",
language = "English",
volume = "141",
pages = "143--156",
journal = "Journal of Supercritical Fluids",
issn = "0896-8446",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process

AU - Lessa Matos, Ravenna

AU - Lu, Tiejun

AU - McConville, Christopher

AU - Leeke, Gary

AU - Ingram, Andy

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Dry powder formulations with potential application in pulmonary drug delivery were produced by integrating the Supercritical Antisolvent (SAS) process with a fluidized bed (FB) under pressure. The simultaneous precipitation and coating of curcumin on lactose was performed in a single step combining the advantages of both processes. Ethanol and acetone were used as solvents. The effects of operating parameters: pressure, temperature, drug-lactose mass ratio, solution flow rate and solution concentration on the drug size, morphology and yield were investigated. Due to the high degree of mixing in the fluidized bed, a uniform coating of curcumin onto lactose was achieved with loading efficiency varying from 71.0 to 93.3% and curcumin particle size between 0.41 and 12.08 μm. Solvent-free curcumin particles with reduced crystallinity were produced while the physicochemical properties of the raw materials were not changed.

AB - Dry powder formulations with potential application in pulmonary drug delivery were produced by integrating the Supercritical Antisolvent (SAS) process with a fluidized bed (FB) under pressure. The simultaneous precipitation and coating of curcumin on lactose was performed in a single step combining the advantages of both processes. Ethanol and acetone were used as solvents. The effects of operating parameters: pressure, temperature, drug-lactose mass ratio, solution flow rate and solution concentration on the drug size, morphology and yield were investigated. Due to the high degree of mixing in the fluidized bed, a uniform coating of curcumin onto lactose was achieved with loading efficiency varying from 71.0 to 93.3% and curcumin particle size between 0.41 and 12.08 μm. Solvent-free curcumin particles with reduced crystallinity were produced while the physicochemical properties of the raw materials were not changed.

KW - Coating

KW - Curcumin

KW - Fluidized bed

KW - Lactose

KW - Pulmonary delivery

KW - Supercritical antisolvent

UR - http://www.scopus.com/inward/record.url?scp=85039448155&partnerID=8YFLogxK

UR - https://dspace.lib.cranfield.ac.uk/handle/1826/12900

U2 - 10.1016/j.supflu.2017.12.013

DO - 10.1016/j.supflu.2017.12.013

M3 - Article

AN - SCOPUS:85039448155

VL - 141

SP - 143

EP - 156

JO - Journal of Supercritical Fluids

JF - Journal of Supercritical Fluids

SN - 0896-8446

ER -