Analysis of curcumin precipitation and coating on lactose by the integrated supercritical antisolvent-fluidized bed process

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Colleges, School and Institutes


Dry powder formulations with potential application in pulmonary drug delivery were produced by integrating the Supercritical Antisolvent (SAS) process with a fluidized bed (FB) under pressure. The simultaneous precipitation and coating of curcumin on lactose was performed in a single step combining the advantages of both processes. Ethanol and acetone were used as solvents. The effects of operating parameters: pressure, temperature, drug-lactose mass ratio, solution flow rate and solution concentration on the drug size, morphology and yield were investigated. Due to the high degree of mixing in the fluidized bed, a uniform coating of curcumin onto lactose was achieved with loading efficiency varying from 71.0 to 93.3% and curcumin particle size between 0.41 and 12.08 μm. Solvent-free curcumin particles with reduced crystallinity were produced while the physicochemical properties of the raw materials were not changed.


Original languageEnglish
Pages (from-to)143-156
Number of pages14
JournalJournal of Supercritical Fluids
Early online date12 Dec 2017
Publication statusPublished - 1 Nov 2018


  • Coating, Curcumin, Fluidized bed, Lactose, Pulmonary delivery, Supercritical antisolvent