An observational study of endothelial function in early arthritis.

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An observational study of endothelial function in early arthritis. / Foster, W; Lip, Gregory; Raza, Karim; Carruthers, David; Blann, Andrew.

In: European journal of clinical investigation, Vol. 42, No. 5, 05.2012, p. 510-516.

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@article{bdb9ccb6724a4bd4b11e30ac3e0ba56b,
title = "An observational study of endothelial function in early arthritis.",
abstract = "Eur J Clin Invest 2011 ABSTRACT: Background  Endothelial dysfunction is present in established rheumatoid arthritis, but it is not clear at what stage of the disease this abnormality develops. We set out to determine whether endothelial damage/dysfunction is present in a group of patients with early arthritis (EA) (new onset inflammatory arthritis, EA). Materials and methods  Eighteen patients with EA, 48 healthy controls and 25 disease controls were recruited. Plasma was obtained for endothelial [von Willebrand factor (vWF) and soluble E-selectin] and angiogenesis markers (vascular endothelial growth factor and its receptor sFlt-1), adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1) and circulating endothelial cells (CECs, as a marker of endothelial damage). Microvascular endothelial function was assessed using laser Doppler perfusion imaging and macrovascular function using flow-mediated dilatation of the brachial artery. Results  von Willebrand factor and CECs (both P ",
author = "W Foster and Gregory Lip and Karim Raza and David Carruthers and Andrew Blann",
year = "2012",
month = may,
doi = "10.1111/j.1365-2362.2011.02607.x",
language = "English",
volume = "42",
pages = "510--516",
journal = "European journal of clinical investigation",
issn = "0014-2972",
publisher = "Wiley",
number = "5",

}

RIS

TY - JOUR

T1 - An observational study of endothelial function in early arthritis.

AU - Foster, W

AU - Lip, Gregory

AU - Raza, Karim

AU - Carruthers, David

AU - Blann, Andrew

PY - 2012/5

Y1 - 2012/5

N2 - Eur J Clin Invest 2011 ABSTRACT: Background  Endothelial dysfunction is present in established rheumatoid arthritis, but it is not clear at what stage of the disease this abnormality develops. We set out to determine whether endothelial damage/dysfunction is present in a group of patients with early arthritis (EA) (new onset inflammatory arthritis, EA). Materials and methods  Eighteen patients with EA, 48 healthy controls and 25 disease controls were recruited. Plasma was obtained for endothelial [von Willebrand factor (vWF) and soluble E-selectin] and angiogenesis markers (vascular endothelial growth factor and its receptor sFlt-1), adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1) and circulating endothelial cells (CECs, as a marker of endothelial damage). Microvascular endothelial function was assessed using laser Doppler perfusion imaging and macrovascular function using flow-mediated dilatation of the brachial artery. Results  von Willebrand factor and CECs (both P 

AB - Eur J Clin Invest 2011 ABSTRACT: Background  Endothelial dysfunction is present in established rheumatoid arthritis, but it is not clear at what stage of the disease this abnormality develops. We set out to determine whether endothelial damage/dysfunction is present in a group of patients with early arthritis (EA) (new onset inflammatory arthritis, EA). Materials and methods  Eighteen patients with EA, 48 healthy controls and 25 disease controls were recruited. Plasma was obtained for endothelial [von Willebrand factor (vWF) and soluble E-selectin] and angiogenesis markers (vascular endothelial growth factor and its receptor sFlt-1), adhesion molecules (intercellular adhesion molecule 1 and vascular cell adhesion molecule 1) and circulating endothelial cells (CECs, as a marker of endothelial damage). Microvascular endothelial function was assessed using laser Doppler perfusion imaging and macrovascular function using flow-mediated dilatation of the brachial artery. Results  von Willebrand factor and CECs (both P 

U2 - 10.1111/j.1365-2362.2011.02607.x

DO - 10.1111/j.1365-2362.2011.02607.x

M3 - Article

C2 - 21985471

VL - 42

SP - 510

EP - 516

JO - European journal of clinical investigation

JF - European journal of clinical investigation

SN - 0014-2972

IS - 5

ER -