An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures

Research output: Contribution to journalArticle

Authors

  • Grace Collord
  • Patrick Tarpey
  • Natalja Kurbatova
  • Inigo Martincorena
  • Sebastian Moran
  • Manuel Castro
  • Tibor Nagy
  • Graham Bignell
  • Francesco Maura
  • Matthew D Young
  • Jorge Berna
  • Jose M C Tubio
  • Chris E McMurran
  • Adam M H Young
  • Mathijs Sanders
  • Imran Noorani
  • Stephen J Price
  • Elke Leipnitz
  • Matthias Kirsch
  • Gabriele Schackert
  • Danita Pearson
  • Abel Devadass
  • Zvi Ram
  • V Peter Collins
  • Kieren Allinson
  • Michael D Jenkinson
  • Rasheed Zakaria
  • Khaja Syed
  • C Oliver Hanemann
  • Jemma Dunn
  • Michael W McDermott
  • Ramez W Kirollos
  • George S Vassiliou
  • Manel Esteller
  • Sam Behjati
  • Alvis Brazma
  • Thomas Santarius
  • Ultan McDermott

Colleges, School and Institutes

Abstract

Anaplastic meningioma is a rare and aggressive brain tumor characterised by intractable recurrences and dismal outcomes. Here, we present an integrated analysis of the whole genome, transcriptome and methylation profiles of primary and recurrent anaplastic meningioma. A key finding was the delineation of distinct molecular subgroups that were associated with diametrically opposed survival outcomes. Relative to lower grade meningiomas, anaplastic tumors harbored frequent driver mutations in SWI/SNF complex genes, which were confined to the poor prognosis subgroup. Aggressive disease was further characterised by transcriptional evidence of increased PRC2 activity, stemness and epithelial-to-mesenchymal transition. Our analyses discern biologically distinct variants of anaplastic meningioma with prognostic and therapeutic significance.

Details

Original languageEnglish
Article number13537
JournalScientific Reports
Volume8
Issue number1
Publication statusPublished - 10 Sep 2018