IncP plasmid carrying the colistin resistance gene mcr-1 in Klebsiella pneumoniae from hospital sewage

Feifei Zhao; Yu Feng; Xiaoju Lü; Alan McNally; Zhiyong Zong

doi:10.1128/AAC.02229-16

IncP plasmid carrying the colistin resistance gene mcr-1 in Klebsiella pneumoniae from hospital sewage

Feifei Zhao, Yu Feng, Xiaoju Lü, Alan McNally, Zhiyong Zong

Medical and Dental Sciences

Research output: Contribution to journal › Article › peer-review

46 Citations (Scopus)

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Abstract

A Klebsiella pneumoniae strain of ST313 recovered from hospital sewage was found to carry the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to be spread beyond the Enterobacteriaceae.

Original language	English
Article number	e02229
Number of pages	6
Journal	Antimicrobial Agents and Chemotherapy
Volume	61
DOIs	https://doi.org/10.1128/AAC.02229-16
Publication status	Published - 24 Jan 2017

Keywords

colistin resistance
mcr-1
sewage
Klebsiella pneumoniae

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Zhao_et_al_An_IncP_plasmid_carrying_Antimicrobial_Agents_and_Chemotherapy_2017Accepted author manuscript, 304 KBLicence: None: All rights reserved

http://aac.asm.org/content/early/2016/11/22/AAC.02229-16Licence: None: All rights reserved

Cite this

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title = "IncP plasmid carrying the colistin resistance gene mcr-1 in Klebsiella pneumoniae from hospital sewage",

abstract = "A Klebsiella pneumoniae strain of ST313 recovered from hospital sewage was found to carry the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to be spread beyond the Enterobacteriaceae.",

keywords = "colistin resistance , mcr-1, sewage , Klebsiella pneumoniae",

author = "Feifei Zhao and Yu Feng and Xiaoju L{\"u} and Alan McNally and Zhiyong Zong",

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AU - Zhao, Feifei

AU - Feng, Yu

AU - Lü, Xiaoju

AU - McNally, Alan

AU - Zong, Zhiyong

PY - 2017/1/24

Y1 - 2017/1/24

N2 - A Klebsiella pneumoniae strain of ST313 recovered from hospital sewage was found to carry the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to be spread beyond the Enterobacteriaceae.

AB - A Klebsiella pneumoniae strain of ST313 recovered from hospital sewage was found to carry the plasmid-borne colistin resistance gene mcr-1, which was bracketed by two copies of the insertion sequence ISApl1 on a 57-kb self-transmissible IncP type plasmid of a new IncP-1 clade. The carriage of mcr-1 on a self-transmissible broad-host-range plasmid highlights that mcr-1 has the potential to be spread beyond the Enterobacteriaceae.

KW - colistin resistance

KW - mcr-1

KW - sewage

KW - Klebsiella pneumoniae

U2 - 10.1128/AAC.02229-16

DO - 10.1128/AAC.02229-16

M3 - Article

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SN - 0066-4804

VL - 61

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

M1 - e02229

ER -

IncP plasmid carrying the colistin resistance gene mcr-1 in Klebsiella pneumoniae from hospital sewage

Abstract

Keywords

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