An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma

Research output: Contribution to journalArticle

Standard

An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. / Iltzsche, Fabian; Simon, Katja; Stopp, Sabine; Pattschull, Grit ; Francke, Sven ; Wolter, Patrick ; Hauser, Stefanie ; Murphy, Daniel; Garcia, Paloma; Rosenwald, Andreas ; Gaubatz, Stefan.

In: Oncogene, 23.05.2016.

Research output: Contribution to journalArticle

Harvard

Iltzsche, F, Simon, K, Stopp, S, Pattschull, G, Francke, S, Wolter, P, Hauser, S, Murphy, D, Garcia, P, Rosenwald, A & Gaubatz, S 2016, 'An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma', Oncogene. https://doi.org/10.1038/onc.2016.181

APA

Iltzsche, F., Simon, K., Stopp, S., Pattschull, G., Francke, S., Wolter, P., Hauser, S., Murphy, D., Garcia, P., Rosenwald, A., & Gaubatz, S. (2016). An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. Oncogene. https://doi.org/10.1038/onc.2016.181

Vancouver

Author

Iltzsche, Fabian ; Simon, Katja ; Stopp, Sabine ; Pattschull, Grit ; Francke, Sven ; Wolter, Patrick ; Hauser, Stefanie ; Murphy, Daniel ; Garcia, Paloma ; Rosenwald, Andreas ; Gaubatz, Stefan. / An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma. In: Oncogene. 2016.

Bibtex

@article{707f4d90c3394a28b9e9f2fae8d59d6d,
title = "An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma",
abstract = "The conserved Myb-MuvB (MMB) multiprotein complex has an important role in transcriptional activation of mitotic genes. MMB target genes are overexpressed in several different cancer types and their elevated expression is associated with an advanced tumor state and a poor prognosis. This suggests that MMB could contribute to tumorigenesis by mediating overexpression of mitotic genes. However, although MMB has been extensively characterized biochemically, the requirement for MMB in tumorigenesis in vivo has not been investigated. Here we demonstrate that MMB is required for tumor formation in a mouse model of lung cancer driven by oncogenic K-RAS. We also identify a requirement for the mitotic kinesin KIF23, a key target gene of MMB, in tumorigenesis. RNA interference-mediated depletion of KIF23 inhibited lung tumor formation in vivo and induced apoptosis in lung cancer cell lines. Our results suggest that inhibition of KIF23 could be a strategy for treatment of lung cancer.",
author = "Fabian Iltzsche and Katja Simon and Sabine Stopp and Grit Pattschull and Sven Francke and Patrick Wolter and Stefanie Hauser and Daniel Murphy and Paloma Garcia and Andreas Rosenwald and Stefan Gaubatz",
year = "2016",
month = may
day = "23",
doi = "10.1038/onc.2016.181",
language = "English",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma

AU - Iltzsche, Fabian

AU - Simon, Katja

AU - Stopp, Sabine

AU - Pattschull, Grit

AU - Francke, Sven

AU - Wolter, Patrick

AU - Hauser, Stefanie

AU - Murphy, Daniel

AU - Garcia, Paloma

AU - Rosenwald, Andreas

AU - Gaubatz, Stefan

PY - 2016/5/23

Y1 - 2016/5/23

N2 - The conserved Myb-MuvB (MMB) multiprotein complex has an important role in transcriptional activation of mitotic genes. MMB target genes are overexpressed in several different cancer types and their elevated expression is associated with an advanced tumor state and a poor prognosis. This suggests that MMB could contribute to tumorigenesis by mediating overexpression of mitotic genes. However, although MMB has been extensively characterized biochemically, the requirement for MMB in tumorigenesis in vivo has not been investigated. Here we demonstrate that MMB is required for tumor formation in a mouse model of lung cancer driven by oncogenic K-RAS. We also identify a requirement for the mitotic kinesin KIF23, a key target gene of MMB, in tumorigenesis. RNA interference-mediated depletion of KIF23 inhibited lung tumor formation in vivo and induced apoptosis in lung cancer cell lines. Our results suggest that inhibition of KIF23 could be a strategy for treatment of lung cancer.

AB - The conserved Myb-MuvB (MMB) multiprotein complex has an important role in transcriptional activation of mitotic genes. MMB target genes are overexpressed in several different cancer types and their elevated expression is associated with an advanced tumor state and a poor prognosis. This suggests that MMB could contribute to tumorigenesis by mediating overexpression of mitotic genes. However, although MMB has been extensively characterized biochemically, the requirement for MMB in tumorigenesis in vivo has not been investigated. Here we demonstrate that MMB is required for tumor formation in a mouse model of lung cancer driven by oncogenic K-RAS. We also identify a requirement for the mitotic kinesin KIF23, a key target gene of MMB, in tumorigenesis. RNA interference-mediated depletion of KIF23 inhibited lung tumor formation in vivo and induced apoptosis in lung cancer cell lines. Our results suggest that inhibition of KIF23 could be a strategy for treatment of lung cancer.

U2 - 10.1038/onc.2016.181

DO - 10.1038/onc.2016.181

M3 - Article

JO - Oncogene

JF - Oncogene

SN - 0950-9232

ER -