An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials

Research output: Contribution to journalArticlepeer-review

Standard

Harvard

APA

Vancouver

Author

Bibtex

@article{b26e107a2c9840d6bbb848cea2f4cd0c,
title = "An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials",
abstract = "We developed and validated a new optical mapping system for quantification of electrical activation and repolarisation in murine atria. The system makes use of a novel 2nd generation complementary metal-oxide-semiconductor (CMOS) camera with deliberate oversampling to allow both assessment of electrical activation with high spatial and temporal resolution (128 × 2048 pixels) and reliable assessment of atrial murine repolarisation using post-processing of signals. Optical recordings were taken from isolated, superfused and electrically stimulated murine left atria. The system reliably describes activation sequences, identifies areas of functional block, and allows quantification of conduction velocities and vectors. Furthermore, the system records murine atrial action potentials with comparable duration to both monophasic and transmembrane action potentials in murine atria.",
author = "Yu, {Ting Yue} and Fahima Syeda and Holmes, {Andrew P} and Benjamin Osborne and Hamid Dehghani and Brain, {Keith L} and Paulus Kirchhof and Larissa Fabritz",
note = "Copyright {\textcopyright} 2014. Published by Elsevier Ltd.",
year = "2014",
month = aug,
day = "15",
doi = "10.1016/j.pbiomolbio.2014.07.012",
language = "English",
volume = "115",
pages = "340--348",
journal = "Progress in Biophysics and Molecular Biology",
issn = "0079-6107",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - An automated system using spatial oversampling for optical mapping in murine atria. Development and validation with monophasic and transmembrane action potentials

AU - Yu, Ting Yue

AU - Syeda, Fahima

AU - Holmes, Andrew P

AU - Osborne, Benjamin

AU - Dehghani, Hamid

AU - Brain, Keith L

AU - Kirchhof, Paulus

AU - Fabritz, Larissa

N1 - Copyright © 2014. Published by Elsevier Ltd.

PY - 2014/8/15

Y1 - 2014/8/15

N2 - We developed and validated a new optical mapping system for quantification of electrical activation and repolarisation in murine atria. The system makes use of a novel 2nd generation complementary metal-oxide-semiconductor (CMOS) camera with deliberate oversampling to allow both assessment of electrical activation with high spatial and temporal resolution (128 × 2048 pixels) and reliable assessment of atrial murine repolarisation using post-processing of signals. Optical recordings were taken from isolated, superfused and electrically stimulated murine left atria. The system reliably describes activation sequences, identifies areas of functional block, and allows quantification of conduction velocities and vectors. Furthermore, the system records murine atrial action potentials with comparable duration to both monophasic and transmembrane action potentials in murine atria.

AB - We developed and validated a new optical mapping system for quantification of electrical activation and repolarisation in murine atria. The system makes use of a novel 2nd generation complementary metal-oxide-semiconductor (CMOS) camera with deliberate oversampling to allow both assessment of electrical activation with high spatial and temporal resolution (128 × 2048 pixels) and reliable assessment of atrial murine repolarisation using post-processing of signals. Optical recordings were taken from isolated, superfused and electrically stimulated murine left atria. The system reliably describes activation sequences, identifies areas of functional block, and allows quantification of conduction velocities and vectors. Furthermore, the system records murine atrial action potentials with comparable duration to both monophasic and transmembrane action potentials in murine atria.

U2 - 10.1016/j.pbiomolbio.2014.07.012

DO - 10.1016/j.pbiomolbio.2014.07.012

M3 - Article

C2 - 25130572

VL - 115

SP - 340

EP - 348

JO - Progress in Biophysics and Molecular Biology

JF - Progress in Biophysics and Molecular Biology

SN - 0079-6107

ER -