Abstract
Michael addition of a proline-derived triketopiperazine (TKP) to β-substituted enones and acrylamides, mediated by a cinchona alkaloid catalyst, delivers products possessing a bicyclo[2.2.2]diazaoctane structure in high yield and enantiomeric ratio (er). Further modification of the amide products toward polycyclic scaffolds resembling members of the prenylated alkaloid
family is also demonstrated.
family is also demonstrated.
Original language | English |
---|---|
Pages (from-to) | 1338-1341 |
Number of pages | 4 |
Journal | Organic Letters |
Early online date | 23 Feb 2017 |
DOIs | |
Publication status | E-pub ahead of print - 23 Feb 2017 |