An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA

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An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. / Isenberg, DA; Allen, E; Farewell, V; D'Cruz, D; Alarcón, GS; Aranow, C; Bruce, IN; Dooley, MA; Fortin, PR; Ginzler, EM; Gladman, DD; Hanly, JG; Inanc, M; Kalunian, K; Khamashta, M; Merrill, JT; Nived, O; Petri, M; Ramsey-Goldman, R; Sturfelt, G; Urowitz, M; Wallace, DJ; Gordon, Caroline; Rahman, A.

In: Annals of the Rheumatic Diseases, Vol. 70, 01.01.2011, p. 54-59.

Research output: Contribution to journalArticle

Harvard

Isenberg, DA, Allen, E, Farewell, V, D'Cruz, D, Alarcón, GS, Aranow, C, Bruce, IN, Dooley, MA, Fortin, PR, Ginzler, EM, Gladman, DD, Hanly, JG, Inanc, M, Kalunian, K, Khamashta, M, Merrill, JT, Nived, O, Petri, M, Ramsey-Goldman, R, Sturfelt, G, Urowitz, M, Wallace, DJ, Gordon, C & Rahman, A 2011, 'An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA', Annals of the Rheumatic Diseases, vol. 70, pp. 54-59. https://doi.org/10.1136/ard.2010.132068

APA

Isenberg, DA., Allen, E., Farewell, V., D'Cruz, D., Alarcón, GS., Aranow, C., Bruce, IN., Dooley, MA., Fortin, PR., Ginzler, EM., Gladman, DD., Hanly, JG., Inanc, M., Kalunian, K., Khamashta, M., Merrill, JT., Nived, O., Petri, M., Ramsey-Goldman, R., ... Rahman, A. (2011). An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. Annals of the Rheumatic Diseases, 70, 54-59. https://doi.org/10.1136/ard.2010.132068

Vancouver

Author

Isenberg, DA ; Allen, E ; Farewell, V ; D'Cruz, D ; Alarcón, GS ; Aranow, C ; Bruce, IN ; Dooley, MA ; Fortin, PR ; Ginzler, EM ; Gladman, DD ; Hanly, JG ; Inanc, M ; Kalunian, K ; Khamashta, M ; Merrill, JT ; Nived, O ; Petri, M ; Ramsey-Goldman, R ; Sturfelt, G ; Urowitz, M ; Wallace, DJ ; Gordon, Caroline ; Rahman, A. / An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA. In: Annals of the Rheumatic Diseases. 2011 ; Vol. 70. pp. 54-59.

Bibtex

@article{7957302f23754a949d4cee2ca759ddee,
title = "An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA",
abstract = "Aims To compare the British Isles Lupus Assessment Group (BILAG) 2004, the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) and physician's global assessment (PGA) in assessing flares of disease activity in patients with systemic lupus erythematosus (SLE). METHODS: /st> Sixteen patients with active SLE were assessed by a panel of 16 rheumatologists. The order in which the patients were seen was randomised using a 4×4 Latin square design. Each patient's flare status was determined at each assessment using the BILAG 2004 activity index; the SFI and a PGA. A group of five specialists designated each patient into severe, moderate, mild or no flare categories. RESULTS: /st> The rate of complete agreement (95% CI) of the four individual examining physicians for any flare versus no flare was 81% (55% to 94%), 75% (49% to 90%) and 75% (49% to 90%) for the BILAG 2004 index, SELENA flare instrument and PGA, respectively. The overall agreement between flare defined by BILAG 2004 and the SFI was 81% and when type of flare was considered was 52%. Intraclass correlation coefficients (95% CI), as a measure of internal reliability, were 0.54 (0.32 to 0.78) for BILAG 2004 flare compared with 0.21 (0.08 to 0.48) for SELENA flare and 0.18 (0.06 to 0.45) for PGA. Severe flare was associated with good agreement between the indices but mild/moderate flare was much less consistent. CONCLUSIONS: /st> The assessment of flare in patients with SLE is challenging. No flare and severe flare are identifiable but further work is needed to optimise the accurate 'capture' of mild and moderate flares.",
author = "DA Isenberg and E Allen and V Farewell and D D'Cruz and GS Alarc{\'o}n and C Aranow and IN Bruce and MA Dooley and PR Fortin and EM Ginzler and DD Gladman and JG Hanly and M Inanc and K Kalunian and M Khamashta and JT Merrill and O Nived and M Petri and R Ramsey-Goldman and G Sturfelt and M Urowitz and DJ Wallace and Caroline Gordon and A Rahman",
year = "2011",
month = jan,
day = "1",
doi = "10.1136/ard.2010.132068",
language = "English",
volume = "70",
pages = "54--59",
journal = "Annals of the Rheumatic Diseases",
issn = "0003-4967",
publisher = "BMJ Publishing Group",

}

RIS

TY - JOUR

T1 - An assessment of disease flare in patients with systemic lupus erythematosus: a comparison of BILAG 2004 and the flare version of SELENA

AU - Isenberg, DA

AU - Allen, E

AU - Farewell, V

AU - D'Cruz, D

AU - Alarcón, GS

AU - Aranow, C

AU - Bruce, IN

AU - Dooley, MA

AU - Fortin, PR

AU - Ginzler, EM

AU - Gladman, DD

AU - Hanly, JG

AU - Inanc, M

AU - Kalunian, K

AU - Khamashta, M

AU - Merrill, JT

AU - Nived, O

AU - Petri, M

AU - Ramsey-Goldman, R

AU - Sturfelt, G

AU - Urowitz, M

AU - Wallace, DJ

AU - Gordon, Caroline

AU - Rahman, A

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Aims To compare the British Isles Lupus Assessment Group (BILAG) 2004, the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) and physician's global assessment (PGA) in assessing flares of disease activity in patients with systemic lupus erythematosus (SLE). METHODS: /st> Sixteen patients with active SLE were assessed by a panel of 16 rheumatologists. The order in which the patients were seen was randomised using a 4×4 Latin square design. Each patient's flare status was determined at each assessment using the BILAG 2004 activity index; the SFI and a PGA. A group of five specialists designated each patient into severe, moderate, mild or no flare categories. RESULTS: /st> The rate of complete agreement (95% CI) of the four individual examining physicians for any flare versus no flare was 81% (55% to 94%), 75% (49% to 90%) and 75% (49% to 90%) for the BILAG 2004 index, SELENA flare instrument and PGA, respectively. The overall agreement between flare defined by BILAG 2004 and the SFI was 81% and when type of flare was considered was 52%. Intraclass correlation coefficients (95% CI), as a measure of internal reliability, were 0.54 (0.32 to 0.78) for BILAG 2004 flare compared with 0.21 (0.08 to 0.48) for SELENA flare and 0.18 (0.06 to 0.45) for PGA. Severe flare was associated with good agreement between the indices but mild/moderate flare was much less consistent. CONCLUSIONS: /st> The assessment of flare in patients with SLE is challenging. No flare and severe flare are identifiable but further work is needed to optimise the accurate 'capture' of mild and moderate flares.

AB - Aims To compare the British Isles Lupus Assessment Group (BILAG) 2004, the Safety of Estrogens in Lupus Erythematosus National Assessment (SELENA) flare index (SFI) and physician's global assessment (PGA) in assessing flares of disease activity in patients with systemic lupus erythematosus (SLE). METHODS: /st> Sixteen patients with active SLE were assessed by a panel of 16 rheumatologists. The order in which the patients were seen was randomised using a 4×4 Latin square design. Each patient's flare status was determined at each assessment using the BILAG 2004 activity index; the SFI and a PGA. A group of five specialists designated each patient into severe, moderate, mild or no flare categories. RESULTS: /st> The rate of complete agreement (95% CI) of the four individual examining physicians for any flare versus no flare was 81% (55% to 94%), 75% (49% to 90%) and 75% (49% to 90%) for the BILAG 2004 index, SELENA flare instrument and PGA, respectively. The overall agreement between flare defined by BILAG 2004 and the SFI was 81% and when type of flare was considered was 52%. Intraclass correlation coefficients (95% CI), as a measure of internal reliability, were 0.54 (0.32 to 0.78) for BILAG 2004 flare compared with 0.21 (0.08 to 0.48) for SELENA flare and 0.18 (0.06 to 0.45) for PGA. Severe flare was associated with good agreement between the indices but mild/moderate flare was much less consistent. CONCLUSIONS: /st> The assessment of flare in patients with SLE is challenging. No flare and severe flare are identifiable but further work is needed to optimise the accurate 'capture' of mild and moderate flares.

U2 - 10.1136/ard.2010.132068

DO - 10.1136/ard.2010.132068

M3 - Article

C2 - 20833737

VL - 70

SP - 54

EP - 59

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

ER -