An analysis of type-III secretion gene clusters in Chromobacterium violaceum

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Authors

Colleges, School and Institutes

Abstract

Chromobacterium violaceum is an environmental Gramnegative bacterium that is common in soil and water in tropical and sub-tropical regions. It is also a model organism for studying quorum-sensing and is a rare but deadly human pathogen. Recent completion of the genome sequence of C. violaceurn strain ATCC 12472 revealed the presence of genes associated with type-III secretion systems (TTSSs). One of these systems resembles the Spi-1 system found in Salmonella enterica, whereas another is similar to the Spi-2 system from the same organism. Here, we present a detailed analysis and a fresh annotation of the two gene clusters. Moreover, we highlight the presence of several genes encoding putative type-III effector proteins that lead us to predict that this organism can manipulate vesicular trafficking, the actin cytoskeleton and apoptotic pathways within mammalian cells to its own advantage.

Details

Original languageEnglish
Pages (from-to)476-482
Number of pages7
JournalTrends in Microbiology
Volume12
Issue number11
Publication statusPublished - 1 Jan 2004