An adherent tissue-inspired hydrogel delivery vehicle utilised in primary human glioma models

Matthew J Rowland; Christopher C Parkins; Joseph H McAbee; Anna K Kolb; Robert Hein; Xian Jun Loh; Colin Watts; Oren A Scherman

doi:10.1016/j.biomaterials.2018.05.054

An adherent tissue-inspired hydrogel delivery vehicle utilised in primary human glioma models

Matthew J Rowland, Christopher C Parkins, Joseph H McAbee, Anna K Kolb, Robert Hein, Xian Jun Loh, Colin Watts, Oren A Scherman

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A physical hydrogel cross-linked via the host-guest interactions of cucurbit[8]uril and utilised as an implantable drug-delivery vehicle for the brain is described herein. Constructed from hyaluronic acid, this hydrogel is biocompatible and has a high water content of 98%. The mechanical properties have been characterised by rheology and compared with the modulus of human brain tissue demonstrating the production of a soft material that can be moulded into the cavity it is implanted into following surgical resection. Furthermore, effective delivery of therapeutic compounds and antibodies to primary human glioblastoma cell lines is showcased by a variety of in vitro and ex vivo viability and immunocytochemistry based assays.

Original language	English
Pages (from-to)	199-208
Number of pages	10
Journal	Biomaterials
Volume	179
Early online date	4 Jun 2018
DOIs	https://doi.org/10.1016/j.biomaterials.2018.05.054
Publication status	Published - Oct 2018

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10.1016/j.biomaterials.2018.05.054

https://www.repository.cam.ac.uk/handle/1810/283340Licence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

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title = "An adherent tissue-inspired hydrogel delivery vehicle utilised in primary human glioma models",

abstract = "A physical hydrogel cross-linked via the host-guest interactions of cucurbit[8]uril and utilised as an implantable drug-delivery vehicle for the brain is described herein. Constructed from hyaluronic acid, this hydrogel is biocompatible and has a high water content of 98%. The mechanical properties have been characterised by rheology and compared with the modulus of human brain tissue demonstrating the production of a soft material that can be moulded into the cavity it is implanted into following surgical resection. Furthermore, effective delivery of therapeutic compounds and antibodies to primary human glioblastoma cell lines is showcased by a variety of in vitro and ex vivo viability and immunocytochemistry based assays.",

author = "Rowland, {Matthew J} and Parkins, {Christopher C} and McAbee, {Joseph H} and Kolb, {Anna K} and Robert Hein and Loh, {Xian Jun} and Colin Watts and Scherman, {Oren A}",

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AU - Rowland, Matthew J

AU - Parkins, Christopher C

AU - McAbee, Joseph H

AU - Kolb, Anna K

AU - Hein, Robert

AU - Loh, Xian Jun

AU - Watts, Colin

AU - Scherman, Oren A

PY - 2018/10

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AB - A physical hydrogel cross-linked via the host-guest interactions of cucurbit[8]uril and utilised as an implantable drug-delivery vehicle for the brain is described herein. Constructed from hyaluronic acid, this hydrogel is biocompatible and has a high water content of 98%. The mechanical properties have been characterised by rheology and compared with the modulus of human brain tissue demonstrating the production of a soft material that can be moulded into the cavity it is implanted into following surgical resection. Furthermore, effective delivery of therapeutic compounds and antibodies to primary human glioblastoma cell lines is showcased by a variety of in vitro and ex vivo viability and immunocytochemistry based assays.

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VL - 179

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JO - Biomaterials

JF - Biomaterials

ER -

An adherent tissue-inspired hydrogel delivery vehicle utilised in primary human glioma models

Abstract

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