An adherent tissue-inspired hydrogel delivery vehicle utilised in primary human glioma models

Research output: Contribution to journalArticlepeer-review

Authors

  • Matthew J Rowland
  • Christopher C Parkins
  • Joseph H McAbee
  • Anna K Kolb
  • Robert Hein
  • Xian Jun Loh
  • Oren A Scherman

Colleges, School and Institutes

External organisations

  • University of Cambridge
  • John van Geest Centre for Brain Repair, Department of Clinical, Neurosciences, University of Cambridge, Cambridge, CB2 0PY, UK.
  • Institute of Materials Research and Engineering, A*STAR, 2 Fusionopolis Way, Innovis, Singapore.
  • Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Cambridge, CB2 1EW, UK. Electronic address: oas23@cam.ac.uk.

Abstract

A physical hydrogel cross-linked via the host-guest interactions of cucurbit[8]uril and utilised as an implantable drug-delivery vehicle for the brain is described herein. Constructed from hyaluronic acid, this hydrogel is biocompatible and has a high water content of 98%. The mechanical properties have been characterised by rheology and compared with the modulus of human brain tissue demonstrating the production of a soft material that can be moulded into the cavity it is implanted into following surgical resection. Furthermore, effective delivery of therapeutic compounds and antibodies to primary human glioblastoma cell lines is showcased by a variety of in vitro and ex vivo viability and immunocytochemistry based assays.

Bibliographic note

Copyright © 2018. Published by Elsevier Ltd.

Details

Original languageEnglish
Pages (from-to)199-208
Number of pages10
JournalBiomaterials
Volume179
Early online date4 Jun 2018
Publication statusPublished - Oct 2018